Comparison between hCG and GnRH Agonist for Ovulation Trigger in GnRH Antagonist In-Vitro Fertilization Cycles in a Tertiary Hospital in Malaysia: An observational study
hCG is commonly used as an ovulation trigger in IVF. Its usage is associated with OHSS. GnRH agonist is an alternative to hCG and is associated with reduced incidence of OHSS. This study compared the cycle outcomes of GnRH agonists with hCG as an ovulation trigger in IVF cycles. The medical notes of...
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| Veröffentlicht in: | JBRA assisted reproduction 2024-01, Vol.28 (1), p.21-26 |
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| creator | Aziz, Nor Azimah Ibrahim, Adibah Ramli, Roziana Yaacob, Nasuha Rahman, Siti Nabillah Abdul Ismail, Engku Husna Engku Omar, Ahmad Akram |
| description | hCG is commonly used as an ovulation trigger in IVF. Its usage is associated with OHSS. GnRH agonist is an alternative to hCG and is associated with reduced incidence of OHSS. This study compared the cycle outcomes of GnRH agonists with hCG as an ovulation trigger in IVF cycles.
The medical notes of 209 IVF cycles receiving GnRH agonist and hCG as ovulation trigger over 18 months were reviewed in this retrospective study. The number and quality of mature oocytes, the number and quality of embryos, pregnancy rates, and outcomes were compared using Independent T-test or One-way ANOVA for normal distribution. The Mann-Whitney test or Kruskal-Wallis test was used for not normally distributed. p |
| doi_str_mv | 10.5935/1518-0557.20230066 |
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The medical notes of 209 IVF cycles receiving GnRH agonist and hCG as ovulation trigger over 18 months were reviewed in this retrospective study. The number and quality of mature oocytes, the number and quality of embryos, pregnancy rates, and outcomes were compared using Independent T-test or One-way ANOVA for normal distribution. The Mann-Whitney test or Kruskal-Wallis test was used for not normally distributed. p<0.05 was considered statistically significant.
The cycle outcomes of 107 GnRH agonist-trigger and 102 hCG-trigger were compared. The MII oocytes retrieved and 2PN count was significantly higher in the GnRH agonist trigger group (p<0.001). Clinical pregnancy rate and ongoing pregnancy were higher in the GnRH agonist trigger group but were not statistically significant. The GnRH agonist trigger group was associated with low OHSS than the hCG trigger group (n=2(1.9%) and n=12(11.8%) respectively, p=0.004).
GnRH agonist trigger is an option as a final maturation trigger in high-responder women undergoing IVF or ICSI cycles.</description><identifier>ISSN: 1518-0557</identifier><identifier>ISSN: 1517-5693</identifier><identifier>EISSN: 1518-0557</identifier><identifier>DOI: 10.5935/1518-0557.20230066</identifier><identifier>PMID: 38224580</identifier><language>eng</language><publisher>Brazil: Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction)</publisher><subject>Abdomen ; Body mass index ; Drug dosages ; Embryology ; Embryos ; Follicles ; Hormones ; In vitro fertilization ; Observational studies ; Original ; Ovaries ; Ovulation ; Patients ; Pregnancy ; Reproductive health ; Ultrasonic imaging ; Vascular endothelial growth factor</subject><ispartof>JBRA assisted reproduction, 2024-01, Vol.28 (1), p.21-26</ispartof><rights>2024. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10936917/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10936917/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38224580$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aziz, Nor Azimah</creatorcontrib><creatorcontrib>Ibrahim, Adibah</creatorcontrib><creatorcontrib>Ramli, Roziana</creatorcontrib><creatorcontrib>Yaacob, Nasuha</creatorcontrib><creatorcontrib>Rahman, Siti Nabillah Abdul</creatorcontrib><creatorcontrib>Ismail, Engku Husna Engku</creatorcontrib><creatorcontrib>Omar, Ahmad Akram</creatorcontrib><title>Comparison between hCG and GnRH Agonist for Ovulation Trigger in GnRH Antagonist In-Vitro Fertilization Cycles in a Tertiary Hospital in Malaysia: An observational study</title><title>JBRA assisted reproduction</title><addtitle>JBRA Assist Reprod</addtitle><description>hCG is commonly used as an ovulation trigger in IVF. Its usage is associated with OHSS. GnRH agonist is an alternative to hCG and is associated with reduced incidence of OHSS. This study compared the cycle outcomes of GnRH agonists with hCG as an ovulation trigger in IVF cycles.
The medical notes of 209 IVF cycles receiving GnRH agonist and hCG as ovulation trigger over 18 months were reviewed in this retrospective study. The number and quality of mature oocytes, the number and quality of embryos, pregnancy rates, and outcomes were compared using Independent T-test or One-way ANOVA for normal distribution. The Mann-Whitney test or Kruskal-Wallis test was used for not normally distributed. p<0.05 was considered statistically significant.
The cycle outcomes of 107 GnRH agonist-trigger and 102 hCG-trigger were compared. The MII oocytes retrieved and 2PN count was significantly higher in the GnRH agonist trigger group (p<0.001). Clinical pregnancy rate and ongoing pregnancy were higher in the GnRH agonist trigger group but were not statistically significant. The GnRH agonist trigger group was associated with low OHSS than the hCG trigger group (n=2(1.9%) and n=12(11.8%) respectively, p=0.004).
GnRH agonist trigger is an option as a final maturation trigger in high-responder women undergoing IVF or ICSI cycles.</description><subject>Abdomen</subject><subject>Body mass index</subject><subject>Drug dosages</subject><subject>Embryology</subject><subject>Embryos</subject><subject>Follicles</subject><subject>Hormones</subject><subject>In vitro fertilization</subject><subject>Observational studies</subject><subject>Original</subject><subject>Ovaries</subject><subject>Ovulation</subject><subject>Patients</subject><subject>Pregnancy</subject><subject>Reproductive health</subject><subject>Ultrasonic imaging</subject><subject>Vascular endothelial growth factor</subject><issn>1518-0557</issn><issn>1517-5693</issn><issn>1518-0557</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdksFqGzEQhpfQkoQ0L9BDEfTSyyYayavd7aWEpbEDKYHg9Cq08qyjsJZcSevgvlHfstrYMWlPEjPf_zPDP1n2EehFUfPiEgqocloU5QWjjFMqxFF2eii-e_M_yc5DeKKUQg2MT-hxdsIrxiZFRU-zP41brZU3wVnSYnxGtOSxmRJlF2Rq72fkaumsCZF0zpO7zdCraBI692a5RE-M3VM2qj14Y_OfJnpHrtFH05vfO0Wz1T2GUaDIfOwovyUzF9Ymqn4s_1C92gajviYz4tqAfvOiTN0Qh8X2Q_a-U33A8_17lj1cf583s_z2bnrTXN3mOm0Vc6hZK3gJXdGWnS610IqXVd3pqtLIWs4YghYMUOuKsooqAYAgANtFy3Ei-Fn2bee7HtoVLjTa6FUv196s0sjSKSP_7VjzKJduI4HWXNRQJocvewfvfg0YolyZoLHvlUU3BMlqSLHQSkBCP_-HPrnBp52D5JSxgtYl0ESxHaW9C8Fjd5gGqByvQY5hyzFs-XoNSfTp7R4HyWv2_C_D2LHK</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Aziz, Nor Azimah</creator><creator>Ibrahim, Adibah</creator><creator>Ramli, Roziana</creator><creator>Yaacob, Nasuha</creator><creator>Rahman, Siti Nabillah Abdul</creator><creator>Ismail, Engku Husna Engku</creator><creator>Omar, Ahmad Akram</creator><general>Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction)</general><general>Brazilian Society of Assisted Reproduction</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240101</creationdate><title>Comparison between hCG and GnRH Agonist for Ovulation Trigger in GnRH Antagonist In-Vitro Fertilization Cycles in a Tertiary Hospital in Malaysia: An observational study</title><author>Aziz, Nor Azimah ; Ibrahim, Adibah ; Ramli, Roziana ; Yaacob, Nasuha ; Rahman, Siti Nabillah Abdul ; Ismail, Engku Husna Engku ; Omar, Ahmad Akram</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-192b6371f5b7fc7c6ca3789fc88ce2b322e1c621ecc80280a611e161ebdb3e463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Abdomen</topic><topic>Body mass index</topic><topic>Drug dosages</topic><topic>Embryology</topic><topic>Embryos</topic><topic>Follicles</topic><topic>Hormones</topic><topic>In vitro fertilization</topic><topic>Observational studies</topic><topic>Original</topic><topic>Ovaries</topic><topic>Ovulation</topic><topic>Patients</topic><topic>Pregnancy</topic><topic>Reproductive health</topic><topic>Ultrasonic imaging</topic><topic>Vascular endothelial growth factor</topic><toplevel>online_resources</toplevel><creatorcontrib>Aziz, Nor Azimah</creatorcontrib><creatorcontrib>Ibrahim, Adibah</creatorcontrib><creatorcontrib>Ramli, Roziana</creatorcontrib><creatorcontrib>Yaacob, Nasuha</creatorcontrib><creatorcontrib>Rahman, Siti Nabillah Abdul</creatorcontrib><creatorcontrib>Ismail, Engku Husna Engku</creatorcontrib><creatorcontrib>Omar, Ahmad Akram</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JBRA assisted reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aziz, Nor Azimah</au><au>Ibrahim, Adibah</au><au>Ramli, Roziana</au><au>Yaacob, Nasuha</au><au>Rahman, Siti Nabillah Abdul</au><au>Ismail, Engku Husna Engku</au><au>Omar, Ahmad Akram</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison between hCG and GnRH Agonist for Ovulation Trigger in GnRH Antagonist In-Vitro Fertilization Cycles in a Tertiary Hospital in Malaysia: An observational study</atitle><jtitle>JBRA assisted reproduction</jtitle><addtitle>JBRA Assist Reprod</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>28</volume><issue>1</issue><spage>21</spage><epage>26</epage><pages>21-26</pages><issn>1518-0557</issn><issn>1517-5693</issn><eissn>1518-0557</eissn><abstract>hCG is commonly used as an ovulation trigger in IVF. Its usage is associated with OHSS. GnRH agonist is an alternative to hCG and is associated with reduced incidence of OHSS. This study compared the cycle outcomes of GnRH agonists with hCG as an ovulation trigger in IVF cycles.
The medical notes of 209 IVF cycles receiving GnRH agonist and hCG as ovulation trigger over 18 months were reviewed in this retrospective study. The number and quality of mature oocytes, the number and quality of embryos, pregnancy rates, and outcomes were compared using Independent T-test or One-way ANOVA for normal distribution. The Mann-Whitney test or Kruskal-Wallis test was used for not normally distributed. p<0.05 was considered statistically significant.
The cycle outcomes of 107 GnRH agonist-trigger and 102 hCG-trigger were compared. The MII oocytes retrieved and 2PN count was significantly higher in the GnRH agonist trigger group (p<0.001). Clinical pregnancy rate and ongoing pregnancy were higher in the GnRH agonist trigger group but were not statistically significant. The GnRH agonist trigger group was associated with low OHSS than the hCG trigger group (n=2(1.9%) and n=12(11.8%) respectively, p=0.004).
GnRH agonist trigger is an option as a final maturation trigger in high-responder women undergoing IVF or ICSI cycles.</abstract><cop>Brazil</cop><pub>Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction)</pub><pmid>38224580</pmid><doi>10.5935/1518-0557.20230066</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Abdomen Body mass index Drug dosages Embryology Embryos Follicles Hormones In vitro fertilization Observational studies Original Ovaries Ovulation Patients Pregnancy Reproductive health Ultrasonic imaging Vascular endothelial growth factor |
| title | Comparison between hCG and GnRH Agonist for Ovulation Trigger in GnRH Antagonist In-Vitro Fertilization Cycles in a Tertiary Hospital in Malaysia: An observational study |
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