Assessing Squarates as Amine-Reactive Probes

Probes that covalently label protein targets facilitate the identification of ligand-binding sites. Lysine residues are prevalent in the proteome, making them attractive substrates for covalent probes. However, identifying electrophiles that undergo amine-specific, regioselective reactions with bind...

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Veröffentlicht in:	Journal of the American Chemical Society 2023-11, Vol.145 (46), p.25056-25060
Hauptverfasser:	Taylor, Katherine I, Ho, Jordan S, Trial, Hallie O, Carter, Alan W, Kiessling, Laura L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemistry Binding Sites Lysine - chemistry
Online-Zugang:	Volltext
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