Cantharidin and sodium fluoride attenuate the negative inotropic effects of carbachol in the isolated human atrium

Carbachol, an agonist at muscarinic receptors, exerts a negative inotropic effect in human atrium. Carbachol can activate protein phosphatases (PP1 or PP2A). We hypothesized that cantharidin or sodium fluoride, inhibitors of PP1 and PP2A, may attenuate a negative inotropic effect of carbachol. Durin...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2024-04, Vol.397 (4), p.2183-2202
Hauptverfasser:	Schwarz, Rebecca, Hofmann, Britt, Gergs, Ulrich, Neumann, Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (muscarinic) Atrium Biomedical and Life Sciences Biomedicine Carbachol Enzymatic activity Fluorides Isometric Neurosciences Pharmacology/Toxicology Sodium Sodium fluoride
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