KCa2.2 (KCNN2): A physiologically and therapeutically important potassium channel

One group of the K+ ion channels, the small‐conductance Ca2+‐activated potassium channels (KCa2.x, also known as SK channels family), is widely expressed in neurons as well as the heart, endothelial cells, etc. They are named small‐conductance Ca2+‐activated potassium channels (SK channels) due to t...

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Veröffentlicht in:	Journal of neuroscience research 2023-11, Vol.101 (11), p.1699-1710
Hauptverfasser:	Rahman, Mohammad Asikur, Orfali, Razan, Dave, Nikita, Lam, Elyn, Naguib, Nadeen, Young‐Woo Nam, Zhang, Miao
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Afterhyperpolarization Ataxia Calcium (intracellular) Calcium channels Calcium conductance Calcium ions Cerebellar ataxia Cerebellum Chromosome 5 Conductance Disabilities Endothelial cells Excitability Excitatory postsynaptic potentials Extrapyramidal system Haploinsufficiency Intellectual disabilities Ion channels Membrane potential Modulators Movement disorders Mutation Neurodevelopmental disorders Neuromodulation Potassium Potassium channels (calcium-gated) Potassium conductance Purkinje cells Signs and symptoms Spinocerebellar ataxia Therapeutic targets
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