Lymphatic System and the Kidney: From Lymphangiogenesis to Renal Inflammation and Fibrosis Development
The lymphatic kidney system plays a crucial role in managing interstitial fluid removal, regulating fluid balance, and tuning immune response. It also assists in the reabsorption of proteins, electrolytes, cytokines, growth factors, and immune cells. Pathological conditions, including tissue damage,...
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| Veröffentlicht in: | International journal of molecular sciences 2024-03, Vol.25 (5), p.2853 |
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| creator | Stasi, Elodie Sciascia, Savino Naretto, Carla Baldovino, Simone Roccatello, Dario |
| description | The lymphatic kidney system plays a crucial role in managing interstitial fluid removal, regulating fluid balance, and tuning immune response. It also assists in the reabsorption of proteins, electrolytes, cytokines, growth factors, and immune cells. Pathological conditions, including tissue damage, excessive interstitial fluid, high blood glucose levels, and inflammation, can initiate lymphangiogenesis-the formation of new lymphatic vessels. This process is associated with various kidney diseases, including polycystic kidney disease, hypertension, ultrafiltration challenges, and complications post-organ transplantation. Although lymphangiogenesis has beneficial effects in removing excess fluid and immune cells, it may also contribute to inflammation and fibrosis within the kidneys. In this review, we aim to discuss the biology of the lymphatic system, from its development and function to its response to disease stimuli, with an emphasis on renal pathophysiology. Furthermore, we explore how innovative treatments targeting the lymphatic system could potentially enhance the management of kidney diseases. |
| doi_str_mv | 10.3390/ijms25052853 |
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| subjects | Antigens B cells Blood sugar Blood vessels Cytokines Dendritic cells Development and progression Electrolytes Fibrosis Genes Hyperglycemia Hypertension Immune response Inflammation Kidney diseases Lymphatic system Plasma Proteins Review T cell receptors Transcription factors Transplantation of organs, tissues, etc Transplants & implants Veins & arteries |
| title | Lymphatic System and the Kidney: From Lymphangiogenesis to Renal Inflammation and Fibrosis Development |
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