Transjugular Intrahepatic Portosystemic Shunt in Nonmalignant Noncirrhotic Portal Vein Thrombosis and Portosinusoidal Vascular Disorder
Transjugular intrahepatic portosystemic shunt (TIPS) emerges as a key treatment for portal hypertension (PH) complications. While international guidelines provide clear indications for its use in cirrhosis, empirical knowledge is notably scarcer in non-cirrhotic PH, particularly in nonmalignant nonc...
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| Veröffentlicht in: | Journal of clinical medicine 2024-02, Vol.13 (5), p.1412 |
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| creator | Shalaby, Sarah Miraglia, Roberto Senzolo, Marco |
| description | Transjugular intrahepatic portosystemic shunt (TIPS) emerges as a key treatment for portal hypertension (PH) complications. While international guidelines provide clear indications for its use in cirrhosis, empirical knowledge is notably scarcer in non-cirrhotic PH, particularly in nonmalignant noncirrhotic portal vein thrombosis (NNPVT) and in patients with portosinusoidal vascular disorder (PSVD). Patients afflicted by these rare diseases exhibit distinct clinical profiles compared to their cirrhotic counterparts, often characterized by a younger age, predominantly preserved hepatic functionality even in cases of severe PH, and a higher propensity for extensive splanchnic thrombosis, which intricately complicates TIPS placement, posing unique challenges for its creation. The objective of this review is to synthesize existing literature on the effectiveness, safety, specific indications, and clinical outcomes of TIPS in adult patients with NNPVT or PSVD, focusing also on the technical challenges of TIPS insertion in the presence of portal cavernoma. |
| doi_str_mv | 10.3390/jcm13051412 |
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The objective of this review is to synthesize existing literature on the effectiveness, safety, specific indications, and clinical outcomes of TIPS in adult patients with NNPVT or PSVD, focusing also on the technical challenges of TIPS insertion in the presence of portal cavernoma.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm13051412</identifier><identifier>PMID: 38592220</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Abdomen ; Anticoagulants ; Blood circulation disorders ; Blood clots ; Care and treatment ; Health aspects ; Hypertension ; Ischemia ; Liver ; Liver cirrhosis ; Patients ; Portacaval anastomosis ; Review ; Thrombosis ; Vein & artery diseases ; Venous thrombosis</subject><ispartof>Journal of clinical medicine, 2024-02, Vol.13 (5), p.1412</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. 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| subjects | Abdomen Anticoagulants Blood circulation disorders Blood clots Care and treatment Health aspects Hypertension Ischemia Liver Liver cirrhosis Patients Portacaval anastomosis Review Thrombosis Vein & artery diseases Venous thrombosis |
| title | Transjugular Intrahepatic Portosystemic Shunt in Nonmalignant Noncirrhotic Portal Vein Thrombosis and Portosinusoidal Vascular Disorder |
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