Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions

Senolytics, small molecules targeting cellular senescence, have emerged as potential therapeutics to enhance health span. However, their impact on epigenetic age remains unstudied. This study aimed to assess the effects of Dasatinib and Quercetin (DQ) senolytic treatment on DNA methylation (DNAm), e...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2024-02, Vol.16 (4), p.3088-3106
Hauptverfasser:	Lee, Edwin, Carreras-Gallo, Natàlia, Lopez, Leilani, Turner, Logan, Lin, Aaron, Mendez, Tavis L, Went, Hannah, Tomusiak, Alan, Verdin, Eric, Corley, Michael, Ndhlovu, Lishomwa, Smith, Ryan, Dwaraka, Varun B
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Dasatinib - pharmacology Dasatinib - therapeutic use DNA Methylation Epigenesis, Genetic Flavonols Humans Longitudinal Studies Pilot Projects Quercetin - pharmacology Research Paper Senotherapeutics
Online-Zugang:	Volltext
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