Layering vaccination with antibiotic therapy results in protection and clearance of Burkholderia pseudomallei in Balb/c mice

Melioidosis is a disease that is difficult to treat due to the causative organism, being inherently antibiotic resistant and it having the ability to invade, survive, and replicate in an intracellular environment. Combination therapy approaches are routinely being evaluated in animal models with the...

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Veröffentlicht in:	Infection and immunity 2024-03, Vol.92 (3), p.e0045523-e0045523
Hauptverfasser:	Barnes, Kay B, Brett, Paul, Burtnick, Mary, Vente, Andreas, Bentley, Christine, Richards, Mark I, Flick-Smith, Helen C, Burgess, Gary, Thwaite, Joanne E, Laws, Thomas R, Maishman, Thomas C, Nelson, Michelle, Harding, Sarah V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - therapeutic use Antimicrobial Chemotherapy Burkholderia pseudomallei Disease Models, Animal Melioidosis - drug therapy Melioidosis - prevention & control Mice Mice, Inbred BALB C Microbial Immunity and Vaccines Vaccination Vaccines, Subunit
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