Clostridium Bacteria: Harnessing Tumour Necrosis for Targeted Gene Delivery

Necrosis is a common feature of solid tumours that offers a unique opportunity for targeted cancer therapy as it is absent from normal healthy tissues. Tumour necrosis provides an ideal environment for germination of the anaerobic bacterium Clostridium from endospores, resulting in tumour-specific c...

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Veröffentlicht in:	Molecular diagnosis & therapy 2024-03, Vol.28 (2), p.141-151
Hauptverfasser:	Theys, Jan, Patterson, Adam V., Mowday, Alexandra M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Anticancer properties Bacteria Base Composition Biomedical and Life Sciences Biomedicine Cancer Cancer immunotherapy Cancer Research Cancer therapies Clostridium Clostridium - genetics Clostridium - metabolism CRISPR Enzymes Gene transfer Gene Transfer Techniques Genes Genetic modification Genomes Germination Human Genetics Humans Immune checkpoint inhibitors Immunomodulation Immunotherapy Infections Laboratory Medicine Leading Leading Article Molecular Medicine Necrosis Neoplasms - genetics Neoplasms - therapy Pharmacotherapy Phylogeny Plasmids Prodrugs Prodrugs - metabolism RNA, Ribosomal, 16S Sequence Analysis, DNA Solid tumors Strains (organisms) Therapy Toxicity Transgenes Tumor Microenvironment Tumor necrosis factor-α Tumors
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