Small-molecule discovery through DNA-encoded libraries

The development of bioactive small molecules as probes or drug candidates requires discovery platforms that enable access to chemical diversity and can quickly reveal new ligands for a target of interest. Within the past 15 years, DNA-encoded library (DEL) technology has matured into a widely used p...

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Veröffentlicht in:	Nature reviews. Drug discovery 2023-09, Vol.22 (9), p.699-722
Hauptverfasser:	Peterson, Alexander A., Liu, David R.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/1435 631/92/2132/605 Biomedical and Life Sciences Biomedicine Biotechnology Cancer Research DNA - chemistry Drug Discovery - methods Gene Library Humans Ligands Medicinal Chemistry Molecular Medicine Pharmacology/Toxicology Review Article Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology
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