Design, Preclinical Evaluation, and Clinical Translation of 68Ga-FAPI-LM3, a Heterobivalent Molecule for PET Imaging of Nasopharyngeal Carcinoma

Extensive research has been conducted on radiolabeled fibroblast activation protein (FAP) inhibitors (FAPIs) and p-Cl-Phe-cyclo(d-Cys-Tyr-d-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)d-Tyr-NH2 (LM3) peptides for imaging of FAP and somatostatin receptor 2 (SSTR2)–positive tumors. In this study, we designed a...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2024-03, Vol.65 (3), p.394-401
Hauptverfasser:	Zhao, Liang, Pang, Yizhen, Fang, Jianyang, Chen, Jianhao, Zhou, Yangfan, Sun, Long, Wu, Hua, Guo, Zhide, Lin, Qin, Chen, Haojun
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Chemical synthesis Clinical Investigation Computed tomography Feasibility studies Fibroblast activation protein Fluorine isotopes In vivo methods and tests Lesions Medical imaging Metastases Nasopharyngeal carcinoma Peptides Positron emission Positron emission tomography Radiolabelling Receptors Somatostatin Somatostatin receptors Throat cancer Tumors Xenografts Xenotransplantation
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