Estrogen-mediated mechanisms in hypertension and other cardiovascular diseases
Cardiovascular disease (CVD) is the leading cause of death globally for men and women. Premenopausal women have a lower incidence of hypertension and other cardiovascular events than men of the same age, but diminished sex differences after menopause implicates 17-beta-estradiol (E2) as a protective...
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| Veröffentlicht in: | Journal of human hypertension 2023-08, Vol.37 (8), p.609-618 |
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| container_title | Journal of human hypertension |
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| creator | Visniauskas, Bruna Kilanowski-Doroh, Isabella Ogola, Benard O. Mcnally, Alexandra B. Horton, Alec C. Imulinde Sugi, Ariane Lindsey, Sarah H. |
| description | Cardiovascular disease (CVD) is the leading cause of death globally for men and women. Premenopausal women have a lower incidence of hypertension and other cardiovascular events than men of the same age, but diminished sex differences after menopause implicates 17-beta-estradiol (E2) as a protective agent. The cardioprotective effects of E2 are mediated by nuclear estrogen receptors (ERα and ERβ) and a G protein-coupled estrogen receptor (GPER). This review summarizes both established as well as emerging estrogen-mediated mechanisms that underlie sex differences in the vasculature during hypertension and CVD. In addition, remaining knowledge gaps inherent in the association of sex differences and E2 are identified, which may guide future clinical trials and experimental studies in this field. |
| doi_str_mv | 10.1038/s41371-022-00771-0 |
| format | Article |
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Premenopausal women have a lower incidence of hypertension and other cardiovascular events than men of the same age, but diminished sex differences after menopause implicates 17-beta-estradiol (E2) as a protective agent. The cardioprotective effects of E2 are mediated by nuclear estrogen receptors (ERα and ERβ) and a G protein-coupled estrogen receptor (GPER). This review summarizes both established as well as emerging estrogen-mediated mechanisms that underlie sex differences in the vasculature during hypertension and CVD. In addition, remaining knowledge gaps inherent in the association of sex differences and E2 are identified, which may guide future clinical trials and experimental studies in this field.</description><identifier>ISSN: 1476-5527</identifier><identifier>ISSN: 0950-9240</identifier><identifier>EISSN: 1476-5527</identifier><identifier>DOI: 10.1038/s41371-022-00771-0</identifier><identifier>PMID: 36319856</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>17β-Estradiol ; 631/443/592/75/243 ; 631/443/7 ; Age ; Androgens ; Blood pressure ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - etiology ; Clinical trials ; Epidemiology ; Estradiol - pharmacology ; Estrogen receptors ; Estrogens ; Female ; Females ; Gender differences ; Health Administration ; Heart failure ; Humans ; Hypertension ; Hypertension - complications ; Hypertension - drug therapy ; Male ; Males ; Medicine ; Medicine & Public Health ; Menopause ; Metabolites ; Nitric oxide ; Public Health ; Receptors, Estrogen ; Receptors, G-Protein-Coupled ; Review Article ; Sex differences ; Smooth muscle ; Stroke ; Womens health</subject><ispartof>Journal of human hypertension, 2023-08, Vol.37 (8), p.609-618</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2022. 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Premenopausal women have a lower incidence of hypertension and other cardiovascular events than men of the same age, but diminished sex differences after menopause implicates 17-beta-estradiol (E2) as a protective agent. The cardioprotective effects of E2 are mediated by nuclear estrogen receptors (ERα and ERβ) and a G protein-coupled estrogen receptor (GPER). This review summarizes both established as well as emerging estrogen-mediated mechanisms that underlie sex differences in the vasculature during hypertension and CVD. 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| subjects | 17β-Estradiol 631/443/592/75/243 631/443/7 Age Androgens Blood pressure Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - etiology Clinical trials Epidemiology Estradiol - pharmacology Estrogen receptors Estrogens Female Females Gender differences Health Administration Heart failure Humans Hypertension Hypertension - complications Hypertension - drug therapy Male Males Medicine Medicine & Public Health Menopause Metabolites Nitric oxide Public Health Receptors, Estrogen Receptors, G-Protein-Coupled Review Article Sex differences Smooth muscle Stroke Womens health |
| title | Estrogen-mediated mechanisms in hypertension and other cardiovascular diseases |
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