The effect of abatacept on T-cell activation is not long-lived in vivo

Abstract Abatacept, a co-stimulatory blocker comprising the extracellular portion of human CTLA-4 linked to the Fc region of IgG1, is approved for the treatment of rheumatoid arthritis. By impairing the interaction between CD28 on T cells and CD80/CD86 on APCs, its mechanisms of action include the s...

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Veröffentlicht in:	Discovery immunology 2024, Vol.3 (1), p.kyad029-kyad029
Hauptverfasser:	da Rosa, Larissa C, Scales, Hannah E, Benson, Robert A, Brewer, James M, McInnes, Iain B, Garside, Paul
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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