The effect of abatacept on T-cell activation is not long-lived in vivo

The effect of abatacept on T-cell activation is not long-lived in vivo

Abstract Abatacept, a co-stimulatory blocker comprising the extracellular portion of human CTLA-4 linked to the Fc region of IgG1, is approved for the treatment of rheumatoid arthritis. By impairing the interaction between CD28 on T cells and CD80/CD86 on APCs, its mechanisms of action include the s...

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Veröffentlicht in:Discovery immunology 2024, Vol.3 (1), p.kyad029-kyad029
Hauptverfasser: da Rosa, Larissa C, Scales, Hannah E, Benson, Robert A, Brewer, James M, McInnes, Iain B, Garside, Paul
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container_issue 1
container_start_page kyad029
container_title Discovery immunology
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creator da Rosa, Larissa C
Scales, Hannah E
Benson, Robert A
Brewer, James M
McInnes, Iain B
Garside, Paul
description Abstract Abatacept, a co-stimulatory blocker comprising the extracellular portion of human CTLA-4 linked to the Fc region of IgG1, is approved for the treatment of rheumatoid arthritis. By impairing the interaction between CD28 on T cells and CD80/CD86 on APCs, its mechanisms of action include the suppression of follicular T helper cells (preventing the breach of self-tolerance in B cells), inhibition of cell cycle progression holding T cells in a state described as ‘induced naïve’ and reduction in DC conditioning. However, less is known about how long these inhibitory effects might last, which is a critical question for therapeutic use in patients. Herein, employing a murine model of OVA-induced DTH, we demonstrate that the effect of abatacept is short-lived in vivo and that the inhibitory effects diminish markedly when treatment is ceased. Graphical Abstract Graphical Abstract
doi_str_mv 10.1093/discim/kyad029
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title The effect of abatacept on T-cell activation is not long-lived in vivo
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