Histamine-releasing factor in severe asthma and rhinovirus-associated asthma exacerbation
[Display omitted] Histamine-releasing factor (HRF) is implicated in allergic diseases. We previously showed its pathogenic role in murine models of asthma. We aim to present data analysis from 3 separate human samples (sera samples from asthmatic patients, nasal washings from rhinovirus [RV]-infecte...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2023-09, Vol.152 (3), p.633-640.e4 |
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| creator | Kawakami, Yu Takazawa, Ikuo Fajt, Merritt L. Kasakura, Kazumi Lin, Joseph Ferrer, Julienne Kantor, David B. Phipatanakul, Wanda Heymann, Peter W. Benedict, Chris A. Kawakami, Yuko Kawakami, Toshiaki |
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Histamine-releasing factor (HRF) is implicated in allergic diseases. We previously showed its pathogenic role in murine models of asthma.
We aim to present data analysis from 3 separate human samples (sera samples from asthmatic patients, nasal washings from rhinovirus [RV]-infected individuals, and sera samples from patients with RV-induced asthma exacerbation) and 1 mouse sample to investigate correlates of HRF function in asthma and virus-induced asthma exacerbations.
Total IgE and HRF-reactive IgE/IgG as well as HRF in sera from patients with mild/moderate asthma or severe asthma (SA) and healthy controls (HCs) were quantified by ELISA. HRF secretion in culture media from RV-infected adenovirus-12 SV40 hybrid virus transformed human bronchial epithelial cells and in nasal washings from experimentally RV-infected subjects was analyzed by Western blotting. HRF-reactive IgE/IgG levels in longitudinal serum samples from patients with asthma exacerbations were also quantified.
HRF-reactive IgE and total IgE levels were higher in patients with SA than in HCs, whereas HRF-reactive IgG (and IgG1) level was lower in asthmatic patients versus HCs. In comparison with HRF-reactive IgElow asthmatic patients, HRF-reactive IgEhigh asthmatic patients had a tendency to release more tryptase and prostaglandin D2 on anti-IgE stimulation of bronchoalveolar lavage cells. RV infection induced HRF secretion from adenovirus-12 SV40 hybrid virus transformed bronchial epithelial cells, and intranasal RV infection of human subjects induced increased HRF secretion in nasal washes. Asthmatic patients had higher levels of HRF-reactive IgE at the time of asthma exacerbations associated with RV infection, compared with those after the resolution. This phenomenon was not seen in asthma exacerbations without viral infections.
HRF-reactive IgE is higher in patients with SA. RV infection induces HRF secretion from respiratory epithelial cells both in vitro and in vivo. These results suggest the role of HRF in asthma severity and RV-induced asthma exacerbation. |
| doi_str_mv | 10.1016/j.jaci.2023.04.021 |
| format | Article |
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Histamine-releasing factor (HRF) is implicated in allergic diseases. We previously showed its pathogenic role in murine models of asthma.
We aim to present data analysis from 3 separate human samples (sera samples from asthmatic patients, nasal washings from rhinovirus [RV]-infected individuals, and sera samples from patients with RV-induced asthma exacerbation) and 1 mouse sample to investigate correlates of HRF function in asthma and virus-induced asthma exacerbations.
Total IgE and HRF-reactive IgE/IgG as well as HRF in sera from patients with mild/moderate asthma or severe asthma (SA) and healthy controls (HCs) were quantified by ELISA. HRF secretion in culture media from RV-infected adenovirus-12 SV40 hybrid virus transformed human bronchial epithelial cells and in nasal washings from experimentally RV-infected subjects was analyzed by Western blotting. HRF-reactive IgE/IgG levels in longitudinal serum samples from patients with asthma exacerbations were also quantified.
HRF-reactive IgE and total IgE levels were higher in patients with SA than in HCs, whereas HRF-reactive IgG (and IgG1) level was lower in asthmatic patients versus HCs. In comparison with HRF-reactive IgElow asthmatic patients, HRF-reactive IgEhigh asthmatic patients had a tendency to release more tryptase and prostaglandin D2 on anti-IgE stimulation of bronchoalveolar lavage cells. RV infection induced HRF secretion from adenovirus-12 SV40 hybrid virus transformed bronchial epithelial cells, and intranasal RV infection of human subjects induced increased HRF secretion in nasal washes. Asthmatic patients had higher levels of HRF-reactive IgE at the time of asthma exacerbations associated with RV infection, compared with those after the resolution. This phenomenon was not seen in asthma exacerbations without viral infections.
HRF-reactive IgE is higher in patients with SA. RV infection induces HRF secretion from respiratory epithelial cells both in vitro and in vivo. These results suggest the role of HRF in asthma severity and RV-induced asthma exacerbation.</description><identifier>ISSN: 0091-6749</identifier><identifier>ISSN: 1097-6825</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2023.04.021</identifier><identifier>PMID: 37301412</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Asthma ; asthma exacerbation ; Enterovirus Infections ; Histamine ; HRF ; Humans ; IgE ; IgG ; Immunoglobulin E ; Immunoglobulin G ; Mice ; Picornaviridae Infections - complications ; Rhinovirus</subject><ispartof>Journal of allergy and clinical immunology, 2023-09, Vol.152 (3), p.633-640.e4</ispartof><rights>2023 American Academy of Allergy, Asthma & Immunology</rights><rights>Copyright © 2023 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c407t-542f1da9f3cfea8bb4eccf8dd81c507dc053c84fa2f79625862db60aab84f3f03</cites><orcidid>0000-0002-0427-1217</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaci.2023.04.021$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37301412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawakami, Yu</creatorcontrib><creatorcontrib>Takazawa, Ikuo</creatorcontrib><creatorcontrib>Fajt, Merritt L.</creatorcontrib><creatorcontrib>Kasakura, Kazumi</creatorcontrib><creatorcontrib>Lin, Joseph</creatorcontrib><creatorcontrib>Ferrer, Julienne</creatorcontrib><creatorcontrib>Kantor, David B.</creatorcontrib><creatorcontrib>Phipatanakul, Wanda</creatorcontrib><creatorcontrib>Heymann, Peter W.</creatorcontrib><creatorcontrib>Benedict, Chris A.</creatorcontrib><creatorcontrib>Kawakami, Yuko</creatorcontrib><creatorcontrib>Kawakami, Toshiaki</creatorcontrib><title>Histamine-releasing factor in severe asthma and rhinovirus-associated asthma exacerbation</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>[Display omitted]
Histamine-releasing factor (HRF) is implicated in allergic diseases. We previously showed its pathogenic role in murine models of asthma.
We aim to present data analysis from 3 separate human samples (sera samples from asthmatic patients, nasal washings from rhinovirus [RV]-infected individuals, and sera samples from patients with RV-induced asthma exacerbation) and 1 mouse sample to investigate correlates of HRF function in asthma and virus-induced asthma exacerbations.
Total IgE and HRF-reactive IgE/IgG as well as HRF in sera from patients with mild/moderate asthma or severe asthma (SA) and healthy controls (HCs) were quantified by ELISA. HRF secretion in culture media from RV-infected adenovirus-12 SV40 hybrid virus transformed human bronchial epithelial cells and in nasal washings from experimentally RV-infected subjects was analyzed by Western blotting. HRF-reactive IgE/IgG levels in longitudinal serum samples from patients with asthma exacerbations were also quantified.
HRF-reactive IgE and total IgE levels were higher in patients with SA than in HCs, whereas HRF-reactive IgG (and IgG1) level was lower in asthmatic patients versus HCs. In comparison with HRF-reactive IgElow asthmatic patients, HRF-reactive IgEhigh asthmatic patients had a tendency to release more tryptase and prostaglandin D2 on anti-IgE stimulation of bronchoalveolar lavage cells. RV infection induced HRF secretion from adenovirus-12 SV40 hybrid virus transformed bronchial epithelial cells, and intranasal RV infection of human subjects induced increased HRF secretion in nasal washes. Asthmatic patients had higher levels of HRF-reactive IgE at the time of asthma exacerbations associated with RV infection, compared with those after the resolution. This phenomenon was not seen in asthma exacerbations without viral infections.
HRF-reactive IgE is higher in patients with SA. RV infection induces HRF secretion from respiratory epithelial cells both in vitro and in vivo. These results suggest the role of HRF in asthma severity and RV-induced asthma exacerbation.</description><subject>Animals</subject><subject>Asthma</subject><subject>asthma exacerbation</subject><subject>Enterovirus Infections</subject><subject>Histamine</subject><subject>HRF</subject><subject>Humans</subject><subject>IgE</subject><subject>IgG</subject><subject>Immunoglobulin E</subject><subject>Immunoglobulin G</subject><subject>Mice</subject><subject>Picornaviridae Infections - complications</subject><subject>Rhinovirus</subject><issn>0091-6749</issn><issn>1097-6825</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo7uzqH_AgffTSbeWjv0AQWdRdWPCiB0-hOqnsZOhO1iQzrP_eHmZ30YunUKmn3oR6GHvDoeHAu_e7ZofGNwKEbEA1IPgztuEw9nU3iPY52wCMvO56NZ6x85x3sNZyGF-yM9lL4IqLDft55XPBxQeqE82E2YfbyqEpMVU-VJkOlKjCXLYLVhhslbY-xINP-1xjztF4LGQfAbpHQ2nC4mN4xV44nDO9fjgv2I8vn79fXtU3375eX366qY2CvtStEo5bHJ00jnCYJkXGuMHagZsWemuglWZQDoXrx060Qyfs1AHitF5KB_KCfTzl3u2nhayhUBLO-i75BdNvHdHrfzvBb_VtPOh1U7znqlsT3j0kpPhrT7noxWdD84yB4j5rMQjVjSCFXFFxQk2KOSdyT-9w0EcpeqePUvRRigalVynr0Nu_f_g08mhhBT6cAFr3dPCUdDaegiHrE5mibfT_y_8D0k2hPQ</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Kawakami, Yu</creator><creator>Takazawa, Ikuo</creator><creator>Fajt, Merritt L.</creator><creator>Kasakura, Kazumi</creator><creator>Lin, Joseph</creator><creator>Ferrer, Julienne</creator><creator>Kantor, David B.</creator><creator>Phipatanakul, Wanda</creator><creator>Heymann, Peter W.</creator><creator>Benedict, Chris A.</creator><creator>Kawakami, Yuko</creator><creator>Kawakami, Toshiaki</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0427-1217</orcidid></search><sort><creationdate>20230901</creationdate><title>Histamine-releasing factor in severe asthma and rhinovirus-associated asthma exacerbation</title><author>Kawakami, Yu ; Takazawa, Ikuo ; Fajt, Merritt L. ; Kasakura, Kazumi ; Lin, Joseph ; Ferrer, Julienne ; Kantor, David B. ; Phipatanakul, Wanda ; Heymann, Peter W. ; Benedict, Chris A. ; Kawakami, Yuko ; Kawakami, Toshiaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-542f1da9f3cfea8bb4eccf8dd81c507dc053c84fa2f79625862db60aab84f3f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Asthma</topic><topic>asthma exacerbation</topic><topic>Enterovirus Infections</topic><topic>Histamine</topic><topic>HRF</topic><topic>Humans</topic><topic>IgE</topic><topic>IgG</topic><topic>Immunoglobulin E</topic><topic>Immunoglobulin G</topic><topic>Mice</topic><topic>Picornaviridae Infections - complications</topic><topic>Rhinovirus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawakami, Yu</creatorcontrib><creatorcontrib>Takazawa, Ikuo</creatorcontrib><creatorcontrib>Fajt, Merritt L.</creatorcontrib><creatorcontrib>Kasakura, Kazumi</creatorcontrib><creatorcontrib>Lin, Joseph</creatorcontrib><creatorcontrib>Ferrer, Julienne</creatorcontrib><creatorcontrib>Kantor, David B.</creatorcontrib><creatorcontrib>Phipatanakul, Wanda</creatorcontrib><creatorcontrib>Heymann, Peter W.</creatorcontrib><creatorcontrib>Benedict, Chris A.</creatorcontrib><creatorcontrib>Kawakami, Yuko</creatorcontrib><creatorcontrib>Kawakami, Toshiaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawakami, Yu</au><au>Takazawa, Ikuo</au><au>Fajt, Merritt L.</au><au>Kasakura, Kazumi</au><au>Lin, Joseph</au><au>Ferrer, Julienne</au><au>Kantor, David B.</au><au>Phipatanakul, Wanda</au><au>Heymann, Peter W.</au><au>Benedict, Chris A.</au><au>Kawakami, Yuko</au><au>Kawakami, Toshiaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histamine-releasing factor in severe asthma and rhinovirus-associated asthma exacerbation</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2023-09-01</date><risdate>2023</risdate><volume>152</volume><issue>3</issue><spage>633</spage><epage>640.e4</epage><pages>633-640.e4</pages><issn>0091-6749</issn><issn>1097-6825</issn><eissn>1097-6825</eissn><abstract>[Display omitted]
Histamine-releasing factor (HRF) is implicated in allergic diseases. We previously showed its pathogenic role in murine models of asthma.
We aim to present data analysis from 3 separate human samples (sera samples from asthmatic patients, nasal washings from rhinovirus [RV]-infected individuals, and sera samples from patients with RV-induced asthma exacerbation) and 1 mouse sample to investigate correlates of HRF function in asthma and virus-induced asthma exacerbations.
Total IgE and HRF-reactive IgE/IgG as well as HRF in sera from patients with mild/moderate asthma or severe asthma (SA) and healthy controls (HCs) were quantified by ELISA. HRF secretion in culture media from RV-infected adenovirus-12 SV40 hybrid virus transformed human bronchial epithelial cells and in nasal washings from experimentally RV-infected subjects was analyzed by Western blotting. HRF-reactive IgE/IgG levels in longitudinal serum samples from patients with asthma exacerbations were also quantified.
HRF-reactive IgE and total IgE levels were higher in patients with SA than in HCs, whereas HRF-reactive IgG (and IgG1) level was lower in asthmatic patients versus HCs. In comparison with HRF-reactive IgElow asthmatic patients, HRF-reactive IgEhigh asthmatic patients had a tendency to release more tryptase and prostaglandin D2 on anti-IgE stimulation of bronchoalveolar lavage cells. RV infection induced HRF secretion from adenovirus-12 SV40 hybrid virus transformed bronchial epithelial cells, and intranasal RV infection of human subjects induced increased HRF secretion in nasal washes. Asthmatic patients had higher levels of HRF-reactive IgE at the time of asthma exacerbations associated with RV infection, compared with those after the resolution. This phenomenon was not seen in asthma exacerbations without viral infections.
HRF-reactive IgE is higher in patients with SA. RV infection induces HRF secretion from respiratory epithelial cells both in vitro and in vivo. These results suggest the role of HRF in asthma severity and RV-induced asthma exacerbation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>37301412</pmid><doi>10.1016/j.jaci.2023.04.021</doi><orcidid>https://orcid.org/0000-0002-0427-1217</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Asthma asthma exacerbation Enterovirus Infections Histamine HRF Humans IgE IgG Immunoglobulin E Immunoglobulin G Mice Picornaviridae Infections - complications Rhinovirus |
| title | Histamine-releasing factor in severe asthma and rhinovirus-associated asthma exacerbation |
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