Sex‐dependent alterations in hippocampal connectivity are linked to cerebrovascular and amyloid pathologies in normal aging

INTRODUCTION Compared to males, females have an accelerated trajectory of cognitive decline in Alzheimer's disease (AD). The neurobiological factors underlying the more rapid cognitive decline in AD in females remain unclear. This study explored how sex‐dependent alterations in hippocampal conn...

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Veröffentlicht in:	Alzheimer's & dementia 2024-02, Vol.20 (2), p.914-924
Hauptverfasser:	Schweitzer, Noah, Li, Jinghang, Thurston, Rebecca C., Lopresti, Brian, Klunk, William E., Snitz, Beth, Tudorascu, Dana, Cohen, Ann, Kamboh, M. Ilyas, Halligan‐Eddy, Edythe, Iordanova, Bistra, Villemagne, Victor L., Aizenstein, Howard, Wu, Minjie
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Alzheimer Disease - pathology Alzheimer's disease Amyloid amyloid beta Amyloid beta-Peptides - metabolism Associative memory Biomarkers Brain - pathology cerebral small vessel disease Cognition & reasoning Cognitive Dysfunction - pathology Cognitive impairment Female Females Functional connectivity Functional magnetic resonance imaging Gender differences hippocampal functional connectivity Hippocampus - pathology Humans Magnetic Resonance Imaging Male Males neural compensation Positron emission tomography sex Tomography white matter hyperintensity
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