Loss of the HOPS complex disrupts early-to-late endosome transition, impairs endosomal recycling and induces accumulation of amphisomes

The multisubunit HOPS tethering complex is a well-established regulator of lysosome fusion with late endosomes and autophagosomes. However, the role of the HOPS complex in other stages of endo-lysosomal trafficking is not well understood. To address this, we made HeLa cells knocked out for the HOPS-...

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Veröffentlicht in:	Molecular biology of the cell 2024-03, Vol.35 (3), p.ar40-ar40
Hauptverfasser:	van der Beek, Jan, de Heus, Cecilia, Sanza, Paolo, Liv, Nalan, Klumperman, Judith
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell organelles Coordination compounds Electron microscopy Identification and classification Methods Properties Proteins Special Issue on Cell Biology of the Lysosome
Online-Zugang:	Volltext
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