Anticancer evaluations of iodoquinazoline substituted with allyl and/or benzyl as dual inhibitors of EGFRWT and EGFRT790M: design, synthesis, ADMET and molecular docking

Fifteen new iodoquinazoline derivatives, 5a,b to 18, are reported in this study and their anticancer evaluation as dual inhibitors of EGFRWT and EGFRT790M. The new derivatives were designed according to the target of structural requirements of receptors. Cytotoxicity of our compounds was evaluated a...

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Veröffentlicht in:	RSC advances 2024-03, Vol.14 (12), p.7964-7980
Hauptverfasser:	Aljohani, Ahmed K B, El-Adl, Khaled, Almohaywi, Basmah, Alatawi, Omar M, Alsulaimany, Marwa, El-morsy, Ahmed, Almadani, Sara A, Alharbi, Hussam Y, Aljohani, Majed S, Felemban Athary Abdulhaleem M, Osman, Hanan E M, Mohamady, Samy
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Cancer Chemical synthesis Chemistry Cytotoxicity Inhibitors Molecular docking Receptors Toxicity
Online-Zugang:	Volltext
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