Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity
Anorexia nervosa (AN) is a severe psychiatric disorder characterized by a harmful persistence of self-imposed starvation resulting in significant weight loss. Research suggests that alterations in the nucleus accumbens (NAcc) and circulating endocannabinoids (eCBs), such as anandamide (AEA) and 2-ar...
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| Veröffentlicht in: | Molecular psychiatry 2023-11, Vol.28 (11), p.4793-4800 |
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| creator | Miranda-Olivos, Romina Baenas, Isabel Steward, Trevor Granero, Roser Pastor, Antoni Sánchez, Isabel Juaneda-Seguí, Asier del Pino-Gutiérrez, Amparo Fernández-Formoso, José A. Vilarrasa, Nuria Guerrero-Pérez, Fernando Virgili, Nuria López-Urdiales, Rafael Jiménez-Murcia, Susana de la Torre, Rafael Soriano-Mas, Carles Fernández-Aranda, Fernando |
| description | Anorexia nervosa (AN) is a severe psychiatric disorder characterized by a harmful persistence of self-imposed starvation resulting in significant weight loss. Research suggests that alterations in the nucleus accumbens (NAcc) and circulating endocannabinoids (eCBs), such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), may contribute to increased severity and maladaptive behaviors in AN, warranting an examination of the interplay between central reward circuitry and eCBs. For this purpose, we assessed NAcc functional connectivity and circulating AEA and 2-AG concentrations in 18 individuals with AN and 18 healthy controls (HC) to test associations between circulating eCBs, NAcc functional connectivity, and AN severity, as defined by body mass index (BMI). Decreased connectivity was observed between the NAcc and the right insula (NAcc-insula;
p
FWE
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| doi_str_mv | 10.1038/s41380-023-02253-2 |
| format | Article |
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p
FWE
< 0.001) and the left supplementary motor area (NAcc-SMA;
p
FWE
< 0.001) in the AN group compared to HC. Reduced NAcc-insula functional connectivity mediated the association between AEA concentrations and BMI in the AN group. However, in HC, NAcc-SMA functional connectivity had a mediating role between AEA concentrations and BMI. Although no significant differences in eCBs concentrations were observed between the groups, our findings provide insights into how the interaction between eCBs and NAcc functional connectivity influences AN severity. Altered NAcc-insula and NAcc-SMA connectivity in AN may impair the integration of interoceptive, somatosensory, and motor planning information related to reward stimuli. Furthermore, the distinct associations between eCBs concentrations and NAcc functional connectivity in AN and HC could have clinical implications for weight maintenance, with eCBs being a potential target for AN treatment.</description><identifier>ISSN: 1359-4184</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/s41380-023-02253-2</identifier><identifier>PMID: 37759041</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>2-Arachidonoylglycerol ; 59/36 ; 631/378 ; 692/699/476 ; 82/58 ; Anandamide ; Anorexia ; Behavioral Sciences ; Biological Psychology ; Body mass index ; Cannabinoids ; Eating disorders ; Medicine ; Medicine & Public Health ; Neurosciences ; Nucleus accumbens ; Pharmacotherapy ; Psychiatry ; Supplementary motor area</subject><ispartof>Molecular psychiatry, 2023-11, Vol.28 (11), p.4793-4800</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c426t-9c923f766f4dd0463b356aa8b7a608fc888fcd9d2a88198603bd2c3dc89947ee3</cites><orcidid>0000-0003-3692-0696 ; 0000-0002-6765-1866 ; 0000-0002-2968-9898 ; 0000-0003-3116-8175 ; 0000-0003-4574-6597</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41380-023-02253-2$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41380-023-02253-2$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37759041$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miranda-Olivos, Romina</creatorcontrib><creatorcontrib>Baenas, Isabel</creatorcontrib><creatorcontrib>Steward, Trevor</creatorcontrib><creatorcontrib>Granero, Roser</creatorcontrib><creatorcontrib>Pastor, Antoni</creatorcontrib><creatorcontrib>Sánchez, Isabel</creatorcontrib><creatorcontrib>Juaneda-Seguí, Asier</creatorcontrib><creatorcontrib>del Pino-Gutiérrez, Amparo</creatorcontrib><creatorcontrib>Fernández-Formoso, José A.</creatorcontrib><creatorcontrib>Vilarrasa, Nuria</creatorcontrib><creatorcontrib>Guerrero-Pérez, Fernando</creatorcontrib><creatorcontrib>Virgili, Nuria</creatorcontrib><creatorcontrib>López-Urdiales, Rafael</creatorcontrib><creatorcontrib>Jiménez-Murcia, Susana</creatorcontrib><creatorcontrib>de la Torre, Rafael</creatorcontrib><creatorcontrib>Soriano-Mas, Carles</creatorcontrib><creatorcontrib>Fernández-Aranda, Fernando</creatorcontrib><title>Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity</title><title>Molecular psychiatry</title><addtitle>Mol Psychiatry</addtitle><addtitle>Mol Psychiatry</addtitle><description>Anorexia nervosa (AN) is a severe psychiatric disorder characterized by a harmful persistence of self-imposed starvation resulting in significant weight loss. Research suggests that alterations in the nucleus accumbens (NAcc) and circulating endocannabinoids (eCBs), such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), may contribute to increased severity and maladaptive behaviors in AN, warranting an examination of the interplay between central reward circuitry and eCBs. For this purpose, we assessed NAcc functional connectivity and circulating AEA and 2-AG concentrations in 18 individuals with AN and 18 healthy controls (HC) to test associations between circulating eCBs, NAcc functional connectivity, and AN severity, as defined by body mass index (BMI). Decreased connectivity was observed between the NAcc and the right insula (NAcc-insula;
p
FWE
< 0.001) and the left supplementary motor area (NAcc-SMA;
p
FWE
< 0.001) in the AN group compared to HC. Reduced NAcc-insula functional connectivity mediated the association between AEA concentrations and BMI in the AN group. However, in HC, NAcc-SMA functional connectivity had a mediating role between AEA concentrations and BMI. Although no significant differences in eCBs concentrations were observed between the groups, our findings provide insights into how the interaction between eCBs and NAcc functional connectivity influences AN severity. Altered NAcc-insula and NAcc-SMA connectivity in AN may impair the integration of interoceptive, somatosensory, and motor planning information related to reward stimuli. Furthermore, the distinct associations between eCBs concentrations and NAcc functional connectivity in AN and HC could have clinical implications for weight maintenance, with eCBs being a potential target for AN treatment.</description><subject>2-Arachidonoylglycerol</subject><subject>59/36</subject><subject>631/378</subject><subject>692/699/476</subject><subject>82/58</subject><subject>Anandamide</subject><subject>Anorexia</subject><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>Body mass index</subject><subject>Cannabinoids</subject><subject>Eating disorders</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosciences</subject><subject>Nucleus accumbens</subject><subject>Pharmacotherapy</subject><subject>Psychiatry</subject><subject>Supplementary motor 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Fernando</au><au>Virgili, Nuria</au><au>López-Urdiales, Rafael</au><au>Jiménez-Murcia, Susana</au><au>de la Torre, Rafael</au><au>Soriano-Mas, Carles</au><au>Fernández-Aranda, Fernando</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity</atitle><jtitle>Molecular psychiatry</jtitle><stitle>Mol Psychiatry</stitle><addtitle>Mol Psychiatry</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>28</volume><issue>11</issue><spage>4793</spage><epage>4800</epage><pages>4793-4800</pages><issn>1359-4184</issn><eissn>1476-5578</eissn><abstract>Anorexia nervosa (AN) is a severe psychiatric disorder characterized by a harmful persistence of self-imposed starvation resulting in significant weight loss. Research suggests that alterations in the nucleus accumbens (NAcc) and circulating endocannabinoids (eCBs), such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), may contribute to increased severity and maladaptive behaviors in AN, warranting an examination of the interplay between central reward circuitry and eCBs. For this purpose, we assessed NAcc functional connectivity and circulating AEA and 2-AG concentrations in 18 individuals with AN and 18 healthy controls (HC) to test associations between circulating eCBs, NAcc functional connectivity, and AN severity, as defined by body mass index (BMI). Decreased connectivity was observed between the NAcc and the right insula (NAcc-insula;
p
FWE
< 0.001) and the left supplementary motor area (NAcc-SMA;
p
FWE
< 0.001) in the AN group compared to HC. Reduced NAcc-insula functional connectivity mediated the association between AEA concentrations and BMI in the AN group. However, in HC, NAcc-SMA functional connectivity had a mediating role between AEA concentrations and BMI. Although no significant differences in eCBs concentrations were observed between the groups, our findings provide insights into how the interaction between eCBs and NAcc functional connectivity influences AN severity. Altered NAcc-insula and NAcc-SMA connectivity in AN may impair the integration of interoceptive, somatosensory, and motor planning information related to reward stimuli. Furthermore, the distinct associations between eCBs concentrations and NAcc functional connectivity in AN and HC could have clinical implications for weight maintenance, with eCBs being a potential target for AN treatment.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>37759041</pmid><doi>10.1038/s41380-023-02253-2</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3692-0696</orcidid><orcidid>https://orcid.org/0000-0002-6765-1866</orcidid><orcidid>https://orcid.org/0000-0002-2968-9898</orcidid><orcidid>https://orcid.org/0000-0003-3116-8175</orcidid><orcidid>https://orcid.org/0000-0003-4574-6597</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 2-Arachidonoylglycerol 59/36 631/378 692/699/476 82/58 Anandamide Anorexia Behavioral Sciences Biological Psychology Body mass index Cannabinoids Eating disorders Medicine Medicine & Public Health Neurosciences Nucleus accumbens Pharmacotherapy Psychiatry Supplementary motor area |
| title | Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity |
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