Carbapenem-resistant Klebsiella pneumoniae capsular types, antibiotic resistance and virulence factors in China: a longitudinal, multi-centre study
Epidemiological knowledge of circulating carbapenem-resistant Klebsiella pneumoniae (CRKP) is needed to develop effective strategies against this public health threat. Here we present a longitudinal analysis of 1,017 CRKP isolates recovered from patients from 40 hospitals across China between 2016 a...
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| Veröffentlicht in: | Nature microbiology 2024-03, Vol.9 (3), p.814-829 |
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| creator | Hu, Fupin Pan, Yuqing Li, Heng Han, Renru Liu, Xiao Ma, Ruijing Wu, Yongqin Lun, Heyuan Qin, Xiaohua Li, Jiayin Wang, Aixi Zhou, Min Liu, Bing Zhou, Zhemin He, Ping |
| description | Epidemiological knowledge of circulating carbapenem-resistant
Klebsiella pneumoniae
(CRKP) is needed to develop effective strategies against this public health threat. Here we present a longitudinal analysis of 1,017 CRKP isolates recovered from patients from 40 hospitals across China between 2016 and 2020. Virulence gene and capsule typing revealed expansion of CRKP capsule type KL64 (59.5%) alongside decreases in KL47 prevalence. Hypervirulent CRKP increased in prevalence from 28.2% in 2016 to 45.7% in 2020. Phylogenetic and spatiotemporal analysis revealed Beijing and Shanghai as transmission hubs accounting for differential geographical prevalence of KL47 and KL64 strains across China. Moderate frequency capsule or O-antigen loss was also detected among isolates. Non-capsular CRKP were more susceptible to phagocytosis, attenuated during mouse infections, but showed increased serum resistance and biofilm formation. These findings give insight into CRKP serotype prevalence and dynamics, revealing the importance of monitoring serotype shifts for the future development of immunological strategies against CRKP infections.
A 5 year longitudinal, retrospective and multi-centre epidemiological study of carbapenem-resistant
Klebsiella pneumoniae
across China reveals antibiotic resistance, virulence gene and capsule profiles for 1,017 isolates showing increased K64 prevalence, increased hypervirulence and moderate frequency, stable circulation of capsule- or O-antigen-deficient strains. |
| doi_str_mv | 10.1038/s41564-024-01612-1 |
| format | Article |
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Klebsiella pneumoniae
(CRKP) is needed to develop effective strategies against this public health threat. Here we present a longitudinal analysis of 1,017 CRKP isolates recovered from patients from 40 hospitals across China between 2016 and 2020. Virulence gene and capsule typing revealed expansion of CRKP capsule type KL64 (59.5%) alongside decreases in KL47 prevalence. Hypervirulent CRKP increased in prevalence from 28.2% in 2016 to 45.7% in 2020. Phylogenetic and spatiotemporal analysis revealed Beijing and Shanghai as transmission hubs accounting for differential geographical prevalence of KL47 and KL64 strains across China. Moderate frequency capsule or O-antigen loss was also detected among isolates. Non-capsular CRKP were more susceptible to phagocytosis, attenuated during mouse infections, but showed increased serum resistance and biofilm formation. These findings give insight into CRKP serotype prevalence and dynamics, revealing the importance of monitoring serotype shifts for the future development of immunological strategies against CRKP infections.
A 5 year longitudinal, retrospective and multi-centre epidemiological study of carbapenem-resistant
Klebsiella pneumoniae
across China reveals antibiotic resistance, virulence gene and capsule profiles for 1,017 isolates showing increased K64 prevalence, increased hypervirulence and moderate frequency, stable circulation of capsule- or O-antigen-deficient strains.</description><identifier>ISSN: 2058-5276</identifier><identifier>EISSN: 2058-5276</identifier><identifier>DOI: 10.1038/s41564-024-01612-1</identifier><identifier>PMID: 38424289</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/44 ; 14 ; 14/28 ; 14/63 ; 38/1 ; 38/77 ; 45/29 ; 631/326/41/1470 ; 631/326/41/2531 ; Antibiotic resistance ; Antibiotics ; Antigens ; Biomedical and Life Sciences ; Carbapenems ; Drug resistance ; Epidemiology ; Infectious Diseases ; Klebsiella pneumoniae ; Life Sciences ; Medical Microbiology ; Microbiology ; Parasitology ; Phagocytosis ; Phylogeny ; Public health ; Virology ; Virulence factors</subject><ispartof>Nature microbiology, 2024-03, Vol.9 (3), p.814-829</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-88a776b12f0b14cf33ee5d894c1836a16bdaf574fdfa43ef8961e1b40bae7e093</citedby><cites>FETCH-LOGICAL-c475t-88a776b12f0b14cf33ee5d894c1836a16bdaf574fdfa43ef8961e1b40bae7e093</cites><orcidid>0000-0002-8005-8119 ; 0000-0001-9783-0366 ; 0000-0003-1449-6003 ; 0000-0002-4493-0619</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41564-024-01612-1$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41564-024-01612-1$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38424289$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Fupin</creatorcontrib><creatorcontrib>Pan, Yuqing</creatorcontrib><creatorcontrib>Li, Heng</creatorcontrib><creatorcontrib>Han, Renru</creatorcontrib><creatorcontrib>Liu, Xiao</creatorcontrib><creatorcontrib>Ma, Ruijing</creatorcontrib><creatorcontrib>Wu, Yongqin</creatorcontrib><creatorcontrib>Lun, Heyuan</creatorcontrib><creatorcontrib>Qin, Xiaohua</creatorcontrib><creatorcontrib>Li, Jiayin</creatorcontrib><creatorcontrib>Wang, Aixi</creatorcontrib><creatorcontrib>Zhou, Min</creatorcontrib><creatorcontrib>Liu, Bing</creatorcontrib><creatorcontrib>Zhou, Zhemin</creatorcontrib><creatorcontrib>He, Ping</creatorcontrib><title>Carbapenem-resistant Klebsiella pneumoniae capsular types, antibiotic resistance and virulence factors in China: a longitudinal, multi-centre study</title><title>Nature microbiology</title><addtitle>Nat Microbiol</addtitle><addtitle>Nat Microbiol</addtitle><description>Epidemiological knowledge of circulating carbapenem-resistant
Klebsiella pneumoniae
(CRKP) is needed to develop effective strategies against this public health threat. Here we present a longitudinal analysis of 1,017 CRKP isolates recovered from patients from 40 hospitals across China between 2016 and 2020. Virulence gene and capsule typing revealed expansion of CRKP capsule type KL64 (59.5%) alongside decreases in KL47 prevalence. Hypervirulent CRKP increased in prevalence from 28.2% in 2016 to 45.7% in 2020. Phylogenetic and spatiotemporal analysis revealed Beijing and Shanghai as transmission hubs accounting for differential geographical prevalence of KL47 and KL64 strains across China. Moderate frequency capsule or O-antigen loss was also detected among isolates. Non-capsular CRKP were more susceptible to phagocytosis, attenuated during mouse infections, but showed increased serum resistance and biofilm formation. These findings give insight into CRKP serotype prevalence and dynamics, revealing the importance of monitoring serotype shifts for the future development of immunological strategies against CRKP infections.
A 5 year longitudinal, retrospective and multi-centre epidemiological study of carbapenem-resistant
Klebsiella pneumoniae
across China reveals antibiotic resistance, virulence gene and capsule profiles for 1,017 isolates showing increased K64 prevalence, increased hypervirulence and moderate frequency, stable circulation of capsule- or O-antigen-deficient strains.</description><subject>13/44</subject><subject>14</subject><subject>14/28</subject><subject>14/63</subject><subject>38/1</subject><subject>38/77</subject><subject>45/29</subject><subject>631/326/41/1470</subject><subject>631/326/41/2531</subject><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>Antigens</subject><subject>Biomedical and Life Sciences</subject><subject>Carbapenems</subject><subject>Drug resistance</subject><subject>Epidemiology</subject><subject>Infectious Diseases</subject><subject>Klebsiella pneumoniae</subject><subject>Life Sciences</subject><subject>Medical Microbiology</subject><subject>Microbiology</subject><subject>Parasitology</subject><subject>Phagocytosis</subject><subject>Phylogeny</subject><subject>Public health</subject><subject>Virology</subject><subject>Virulence factors</subject><issn>2058-5276</issn><issn>2058-5276</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kctu1TAQhiMEolXpC7BAltiwaMC3OA4bhI64iUpsYG05zuTUlWMHXyqd5-CF8TmnLYUFC8uemW9-j_03zXOCXxPM5JvESSd4i2ldRBDakkfNKcWdbDvai8cPzifNeUrXGFeMCiHF0-aESU45lcNp82uj46hX8LC0EZJNWfuMvjoYkwXnNFo9lCV4qwEZvabidER5t0K6QJW0ow3ZGnTXaqBmJ3RjY3Gwj2ZtcogJWY82V9brt0gjF_zW5jLV0F2gpbhsWwM-R0CppnfPmiezdgnOb_ez5sfHD983n9vLb5--bN5ftob3XW6l1H0vRkJnPBJuZsYAukkO3BDJhCZinPTc9XyeZs0ZzHIQBMjI8aihBzyws-bdUXct4wLTYQTt1BrtouNOBW3V3xVvr9Q23CiCB8K7QVaFV7cKMfwskLJabDL7f_MQSlJ0YJz2DMuuoi__Qa9DifUHDlTPB9FTXil6pEwMKUWY76chWO19V0ffVfVdHXxXpDa9ePiO-5Y7lyvAjkCqJb-F-Ofu_8j-Bg4qvO0</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Hu, Fupin</creator><creator>Pan, Yuqing</creator><creator>Li, Heng</creator><creator>Han, Renru</creator><creator>Liu, Xiao</creator><creator>Ma, Ruijing</creator><creator>Wu, Yongqin</creator><creator>Lun, Heyuan</creator><creator>Qin, Xiaohua</creator><creator>Li, Jiayin</creator><creator>Wang, Aixi</creator><creator>Zhou, Min</creator><creator>Liu, Bing</creator><creator>Zhou, Zhemin</creator><creator>He, Ping</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8005-8119</orcidid><orcidid>https://orcid.org/0000-0001-9783-0366</orcidid><orcidid>https://orcid.org/0000-0003-1449-6003</orcidid><orcidid>https://orcid.org/0000-0002-4493-0619</orcidid></search><sort><creationdate>20240301</creationdate><title>Carbapenem-resistant Klebsiella pneumoniae capsular types, antibiotic resistance and virulence factors in China: a longitudinal, multi-centre study</title><author>Hu, Fupin ; 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Klebsiella pneumoniae
(CRKP) is needed to develop effective strategies against this public health threat. Here we present a longitudinal analysis of 1,017 CRKP isolates recovered from patients from 40 hospitals across China between 2016 and 2020. Virulence gene and capsule typing revealed expansion of CRKP capsule type KL64 (59.5%) alongside decreases in KL47 prevalence. Hypervirulent CRKP increased in prevalence from 28.2% in 2016 to 45.7% in 2020. Phylogenetic and spatiotemporal analysis revealed Beijing and Shanghai as transmission hubs accounting for differential geographical prevalence of KL47 and KL64 strains across China. Moderate frequency capsule or O-antigen loss was also detected among isolates. Non-capsular CRKP were more susceptible to phagocytosis, attenuated during mouse infections, but showed increased serum resistance and biofilm formation. These findings give insight into CRKP serotype prevalence and dynamics, revealing the importance of monitoring serotype shifts for the future development of immunological strategies against CRKP infections.
A 5 year longitudinal, retrospective and multi-centre epidemiological study of carbapenem-resistant
Klebsiella pneumoniae
across China reveals antibiotic resistance, virulence gene and capsule profiles for 1,017 isolates showing increased K64 prevalence, increased hypervirulence and moderate frequency, stable circulation of capsule- or O-antigen-deficient strains.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>38424289</pmid><doi>10.1038/s41564-024-01612-1</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-8005-8119</orcidid><orcidid>https://orcid.org/0000-0001-9783-0366</orcidid><orcidid>https://orcid.org/0000-0003-1449-6003</orcidid><orcidid>https://orcid.org/0000-0002-4493-0619</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Springer Online Journals Complete; Nature Journals Online |
| subjects | 13/44 14 14/28 14/63 38/1 38/77 45/29 631/326/41/1470 631/326/41/2531 Antibiotic resistance Antibiotics Antigens Biomedical and Life Sciences Carbapenems Drug resistance Epidemiology Infectious Diseases Klebsiella pneumoniae Life Sciences Medical Microbiology Microbiology Parasitology Phagocytosis Phylogeny Public health Virology Virulence factors |
| title | Carbapenem-resistant Klebsiella pneumoniae capsular types, antibiotic resistance and virulence factors in China: a longitudinal, multi-centre study |
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