Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon

Most organs have tissue-resident immune cells. Human organoids lack these immune cells, which limits their utility in modeling many normal and disease processes. Here, we describe that pluripotent stem cell-derived human colonic organoids (HCOs) co-develop a diverse population of immune cells, inclu...

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Veröffentlicht in:	Cell stem cell 2023-11, Vol.30 (11), p.1434-1451.e9
Hauptverfasser:	Múnera, Jorge O, Kechele, Daniel O, Bouffi, Carine, Qu, Na, Jing, Ran, Maity, Pritiprasanna, Enriquez, Jacob R, Han, Lu, Campbell, Ian, Mahe, Maxime M, McCauley, Heather A, Zhang, Xinghao, Sundaram, Nambirajan, Hudson, Jonathan R, Zarsozo-Lacoste, Adrian, Pradhan, Suman, Tominaga, Kentaro, Sanchez, J Guillermo, Weiss, Alison A, Chatuvedi, Praneet, Spence, Jason R, Hachimi, Mariam, North, Trista, Daley, George Q, Mayhew, Christopher N, Hu, Yueh-Chiang, Takebe, Takanori, Helmrath, Michael A, Wells, James M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Colon Hematopoietic Stem Cells Humans Macrophages Mice Organoids Pluripotent Stem Cells
Online-Zugang:	Volltext
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