ITGB2 fosters the cancerous characteristics of ovarian cancer cells through its role in mitochondrial glycolysis transformation
Related studies have shown that ITGB2 mediates mitochondrial glycolytic transformation in cancer-associated fibroblasts and participates in tumor occurrence, metastasis and invasion of cancer cells. Based on these studies, we tried to construct a mitochondrial glycolysis regulatory network and explo...
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| Veröffentlicht in: | Aging (Albany, NY.) NY.), 2024-02, Vol.16 (3), p.3007-3020 |
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| container_title | Aging (Albany, NY.) |
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| creator | Li, Guo-Wei Jin, Yan-Ping Qiu, Jian-Ping Lu, Xiu-Fang |
| description | Related studies have shown that ITGB2 mediates mitochondrial glycolytic transformation in cancer-associated fibroblasts and participates in tumor occurrence, metastasis and invasion of cancer cells. Based on these studies, we tried to construct a mitochondrial glycolysis regulatory network and explored its effect on mitochondrial homeostasis and ovarian cancer cells' cancerous characteristics. Our research revealed a distinct increase in the expression of ITGB2 and associated signaling pathway elements (PI3K-AKT-mTOR) in cases of ovarian cancer. ITGB2 might control mTOR expression via the PI3K-AKT pathway, thus promote mitochondrial glycolysis transformation and cell energy supply in ovarian cancer. This pathway could also inhibit mitophagy, maintain mitochondrial stability, and enhance the cancerous characteristics in case of ovarian cancer cells by mediating mitochondrial glycolytic transformation. Thus, we concluded that ITGB2-associated signaling route (PI3K-AKT-mTOR) may contribute to the progression of cancerous traits in ovarian cancer via mediating mitochondrial glycolytic transformation. |
| doi_str_mv | 10.18632/aging.205529 |
| format | Article |
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Based on these studies, we tried to construct a mitochondrial glycolysis regulatory network and explored its effect on mitochondrial homeostasis and ovarian cancer cells' cancerous characteristics. Our research revealed a distinct increase in the expression of ITGB2 and associated signaling pathway elements (PI3K-AKT-mTOR) in cases of ovarian cancer. ITGB2 might control mTOR expression via the PI3K-AKT pathway, thus promote mitochondrial glycolysis transformation and cell energy supply in ovarian cancer. This pathway could also inhibit mitophagy, maintain mitochondrial stability, and enhance the cancerous characteristics in case of ovarian cancer cells by mediating mitochondrial glycolytic transformation. Thus, we concluded that ITGB2-associated signaling route (PI3K-AKT-mTOR) may contribute to the progression of cancerous traits in ovarian cancer via mediating mitochondrial glycolytic transformation.</description><identifier>ISSN: 1945-4589</identifier><identifier>EISSN: 1945-4589</identifier><identifier>DOI: 10.18632/aging.205529</identifier><identifier>PMID: 38345576</identifier><language>eng</language><publisher>United States: Impact Journals</publisher><subject>Cell Line, Tumor ; Cell Proliferation ; Female ; Glycolysis ; Humans ; Ovarian Neoplasms - pathology ; Phosphatidylinositol 3-Kinases - metabolism ; Proto-Oncogene Proteins c-akt - metabolism ; Research Paper ; TOR Serine-Threonine Kinases - metabolism</subject><ispartof>Aging (Albany, NY.), 2024-02, Vol.16 (3), p.3007-3020</ispartof><rights>Copyright: © 2024 Guo-Wei et al.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c344t-49510b4cb80fb42e91a32ec683824df61a6e655508e473e86169b9d70d55b6b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10911379/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10911379/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38345576$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Guo-Wei</creatorcontrib><creatorcontrib>Jin, Yan-Ping</creatorcontrib><creatorcontrib>Qiu, Jian-Ping</creatorcontrib><creatorcontrib>Lu, Xiu-Fang</creatorcontrib><title>ITGB2 fosters the cancerous characteristics of ovarian cancer cells through its role in mitochondrial glycolysis transformation</title><title>Aging (Albany, NY.)</title><addtitle>Aging (Albany NY)</addtitle><description>Related studies have shown that ITGB2 mediates mitochondrial glycolytic transformation in cancer-associated fibroblasts and participates in tumor occurrence, metastasis and invasion of cancer cells. Based on these studies, we tried to construct a mitochondrial glycolysis regulatory network and explored its effect on mitochondrial homeostasis and ovarian cancer cells' cancerous characteristics. Our research revealed a distinct increase in the expression of ITGB2 and associated signaling pathway elements (PI3K-AKT-mTOR) in cases of ovarian cancer. ITGB2 might control mTOR expression via the PI3K-AKT pathway, thus promote mitochondrial glycolysis transformation and cell energy supply in ovarian cancer. This pathway could also inhibit mitophagy, maintain mitochondrial stability, and enhance the cancerous characteristics in case of ovarian cancer cells by mediating mitochondrial glycolytic transformation. Thus, we concluded that ITGB2-associated signaling route (PI3K-AKT-mTOR) may contribute to the progression of cancerous traits in ovarian cancer via mediating mitochondrial glycolytic transformation.</description><subject>Cell Line, Tumor</subject><subject>Cell Proliferation</subject><subject>Female</subject><subject>Glycolysis</subject><subject>Humans</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Phosphatidylinositol 3-Kinases - metabolism</subject><subject>Proto-Oncogene Proteins c-akt - metabolism</subject><subject>Research Paper</subject><subject>TOR Serine-Threonine Kinases - metabolism</subject><issn>1945-4589</issn><issn>1945-4589</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkbtPwzAQxi0EorxGVuSRJeB34gkBgoKExAKz5ThOYpTYYKdInfjXcWmpYLqT7nffPT4ATjG6wJWg5FJ3zncXBHFO5A44wJLxgvFK7v7JZ-AwpTeEBOdM7IMZrSjjvBQH4OvxZX5DYBvSZGOCU2-h0d7YGBYJml5HbXLBpcmZBEMLw6eOTvsNBI0dhlVXxrseuinBGAYLnYejm4Lpg28yPsBuWJowLJPLcNQ-tSGOenLBH4O9Vg_JnmziEXi9v3u5fSienuePt9dPhaGMTQWTHKOambpCbc2IlVhTYo2oaEVY0wqshc3HcVRZVlJbCSxkLZsSNZzXohb0CFytdd8X9WgbY33eY1Dv0Y06LlXQTv2veNerLnwqjCTGtJRZ4XyjEMPHwqZJjS6t7tfe5mcpIolAZYlKntFijZoYUoq23c7BSP24pn5cU2vXMn_2d7kt_WsT_QYlqZdw</recordid><startdate>20240211</startdate><enddate>20240211</enddate><creator>Li, Guo-Wei</creator><creator>Jin, Yan-Ping</creator><creator>Qiu, Jian-Ping</creator><creator>Lu, Xiu-Fang</creator><general>Impact Journals</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240211</creationdate><title>ITGB2 fosters the cancerous characteristics of ovarian cancer cells through its role in mitochondrial glycolysis transformation</title><author>Li, Guo-Wei ; Jin, Yan-Ping ; Qiu, Jian-Ping ; Lu, Xiu-Fang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-49510b4cb80fb42e91a32ec683824df61a6e655508e473e86169b9d70d55b6b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cell Line, Tumor</topic><topic>Cell Proliferation</topic><topic>Female</topic><topic>Glycolysis</topic><topic>Humans</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Phosphatidylinositol 3-Kinases - metabolism</topic><topic>Proto-Oncogene Proteins c-akt - metabolism</topic><topic>Research Paper</topic><topic>TOR Serine-Threonine Kinases - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Li, Guo-Wei</creatorcontrib><creatorcontrib>Jin, Yan-Ping</creatorcontrib><creatorcontrib>Qiu, Jian-Ping</creatorcontrib><creatorcontrib>Lu, Xiu-Fang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging (Albany, NY.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Guo-Wei</au><au>Jin, Yan-Ping</au><au>Qiu, Jian-Ping</au><au>Lu, Xiu-Fang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ITGB2 fosters the cancerous characteristics of ovarian cancer cells through its role in mitochondrial glycolysis transformation</atitle><jtitle>Aging (Albany, NY.)</jtitle><addtitle>Aging (Albany NY)</addtitle><date>2024-02-11</date><risdate>2024</risdate><volume>16</volume><issue>3</issue><spage>3007</spage><epage>3020</epage><pages>3007-3020</pages><issn>1945-4589</issn><eissn>1945-4589</eissn><abstract>Related studies have shown that ITGB2 mediates mitochondrial glycolytic transformation in cancer-associated fibroblasts and participates in tumor occurrence, metastasis and invasion of cancer cells. 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| ispartof | Aging (Albany, NY.), 2024-02, Vol.16 (3), p.3007-3020 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Cell Line, Tumor Cell Proliferation Female Glycolysis Humans Ovarian Neoplasms - pathology Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Research Paper TOR Serine-Threonine Kinases - metabolism |
| title | ITGB2 fosters the cancerous characteristics of ovarian cancer cells through its role in mitochondrial glycolysis transformation |
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