Pharmacokinetics of single dose doxycycline in the rectum, vagina, and urethra: implications for prevention of bacterial sexually transmitted infections

Clinical trials showed a single oral dose of doxycycline taken after sex protects against STIs among men who have sex with men (MSM) but not women. Pharmacokinetic data at vaginal, rectal and penile sites of STI exposure are lacking. We examined vaginal, rectal and urethral doxycycline concentration...

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Veröffentlicht in:	EBioMedicine 2024-03, Vol.101, p.105037-105037, Article 105037
Hauptverfasser:	Haaland, Richard E., Fountain, Jeffrey, Edwards, Tiancheng E., Dinh, Chuong, Martin, Amy, Omoyege, Deborah, Conway-Washington, Christopher, Kelley, Colleen F., Heneine, Walid
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Doxycycline Event-driven pre-exposure prophylaxis (PrEP) Pharmacology Post-exposure prophylaxis (PEP) Sexually transmitted infection (STI)
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