Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection

A nasally delivered chimpanzee adenoviral-vectored severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine (ChAd-SARS-CoV-2-S) is currently used in India (iNCOVACC). Here, we update this vaccine by creating ChAd-SARS-CoV-2-BA.5-S, which encodes a prefusion-stabilized BA.5 spike protein....

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Veröffentlicht in:	Nature immunology 2024-03, Vol.25 (3), p.537-551
Hauptverfasser:	Ying, Baoling, Darling, Tamarand L., Desai, Pritesh, Liang, Chieh-Yu, Dmitriev, Igor P., Soudani, Nadia, Bricker, Traci, Kashentseva, Elena A., Harastani, Houda, Raju, Saravanan, Liu, Meizi, Schmidt, Aaron G., Curiel, David T., Boon, Adrianus C. M., Diamond, Michael S.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2152/1566/1571 631/250/590/2293 631/326/596/4130 692/699/255/2514 Biomedical and Life Sciences Biomedicine Bronchopulmonary infection CD8 antigen Coronaviruses COVID-19 Immunological memory Immunology Infections Infectious Diseases Lymphocytes Lymphocytes T Memory cells Monkeys & apes Mucosal immunity Respiratory tract Respiratory tract infection Serum levels Severe acute respiratory syndrome coronavirus 2 Spike protein Vaccines
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