Breaking the symmetry of cell contractility drives tubulogenesis via CXCL1 polarization

The intricate interplay between biomechanical and biochemical pathways in modulating morphogenesis is an interesting research topic. How biomechanical force regulates epithelial cell tubulogenesis remains poorly understood. Here, we established a model of tubulogenesis by culturing renal proximal tu...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2024-02, Vol.121 (9), p.e2315894121
Hauptverfasser:	Kuo, Cheng-Hsiang, Lee, Gang-Hui, Wu, Hua-Lin, Huang, Jyun-Yuan, Tang, Ming-Jer
Format:	Artikel
Sprache:	eng
Schlagworte:	Actomyosin Actomyosin - metabolism Asymmetry Biological Sciences Biomechanics Broken symmetry Collagen Contractility CXC chemokines Cytoskeleton Epithelial cells Epithelial Cells - metabolism Epithelium Extracellular Matrix - metabolism Fibrils Morphogenesis Myosin Polarization Skewed distributions Sonication Symmetry
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