PIEZO1 is a distal nephron mechanosensor and is required for flow-induced K+ secretion

Ca2+-activated BK channels in renal intercalated cells (ICs) mediate luminal flow-induced K+ secretion (FIKS), but how ICs sense increased flow remains uncertain. We examined whether PIEZO1, a mechanosensitive Ca2+-permeable channel expressed in the basolateral membranes of ICs, is required for FIKS...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of clinical investigation 2024-03, Vol.134 (5)
Hauptverfasser:	Carrisoza-Gaytan, Rolando, Mutchler, Stephanie M, Carattino, Francisco, Soong, Joanne, Dalghi, Marianela G, Wu, Peng, Wang, WenHui, Apodaca, Gerard, Satlin, Lisa M, Kleyman, Thomas R
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!