APOL1-mediated monovalent cation transport contributes to APOL1-mediated podocytopathy in kidney disease

Two coding variants of apolipoprotein L1 (APOL1) called G1 and G2 explain much of the excess risk of kidney disease in African Americans. While various cytotoxic phenotypes have been reported in experimental models, the proximal mechanism by which G1 and G2 cause kidney disease is poorly understood....

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Veröffentlicht in:	The Journal of clinical investigation 2024-03, Vol.134 (5)
Hauptverfasser:	Datta, Somenath, Antonio, Brett M, Zahler, Nathan H, Theile, Jonathan W, Krafte, Doug, Zhang, Hengtao, Rosenberg, Paul B, Chaves, Alec B, Muoio, Deborah M, Zhang, Guofang, Silas, Daniel, Li, Guojie, Soldano, Karen, Nystrom, Sarah, Ferreira, Davis, Miller, Sara E, Bain, James R, Muehlbauer, Michael J, Ilkayeva, Olga, Becker, Thomas C, Hohmeier, Hans-Ewald, Newgard, Christopher B, Olabisi, Opeyemi A
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans Amino acids Analysis Apolipoproteins Biological transport Development and progression Genetic aspects Genetic engineering Genetic variation Kidney diseases Negotiation, mediation and arbitration Tetracycline Tetracyclines
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