Increased LL37 in psoriasis and other inflammatory disorders promotes LDL uptake and atherosclerosis

Patients with chronic inflammatory disorders such as psoriasis have an increased risk of cardiovascular disease and elevated levels of LL37, a cathelicidin host defense peptide that has both antimicrobial and proinflammatory properties. To explore whether LL37 could contribute to the risk of heart d...

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Veröffentlicht in:	The Journal of clinical investigation 2024-03, Vol.134 (5)
Hauptverfasser:	Nakamura, Yoshiyuki, Kulkarni, Nikhil N, Takahashi, Toshiya, Alimohamadi, Haleh, Dokoshi, Tatsuya, Liu, Edward, Shia, Michael, Numata, Tomofumi, Luo, Elizabeth Wc, Gombart, Adrian F, Yang, Xiaohong, Secrest, Patrick, Gordts, Philip Lsm, Tsimikas, Sotirios, Wong, Gerard Cl, Gallo, Richard L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Analysis Animals Antimicrobial peptides Atherosclerosis Cardiovascular Diseases Cholesterol Complications and side effects Development and progression Health aspects Heart diseases Humans Inflammation Low density lipoproteins Macrophages Medical research Medicine, Experimental Mice Mice, Knockout, ApoE Peptides Physiological aspects Psoriasis Rabbits Risk factors Scientific equipment and supplies industry
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