A model of human neural networks reveals NPTX2 pathology in ALS and FTLD

Human cellular models of neurodegeneration require reproducibility and longevity, which is necessary for simulating age-dependent diseases. Such systems are particularly needed for TDP-43 proteinopathies 1 , which involve human-specific mechanisms 2 – 5 that cannot be directly studied in animal mode...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 2024-02, Vol.626 (8001), p.1073-1083
Hauptverfasser:	Hruska-Plochan, Marian, Wiersma, Vera I., Betz, Katharina M., Mallona, Izaskun, Ronchi, Silvia, Maniecka, Zuzanna, Hock, Eva-Maria, Tantardini, Elena, Laferriere, Florent, Sahadevan, Sonu, Hoop, Vanessa, Delvendahl, Igor, Pérez-Berlanga, Manuela, Gatta, Beatrice, Panatta, Martina, van der Bourg, Alexander, Bohaciakova, Dasa, Sharma, Puneet, De Vos, Laura, Frontzek, Karl, Aguzzi, Adriano, Lashley, Tammaryn, Robinson, Mark D., Karayannis, Theofanis, Mueller, Martin, Hierlemann, Andreas, Polymenidou, Magdalini
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/100 13/106 13/51 13/89 14 14/1 14/19 14/63 3' Untranslated regions 38 38/1 38/90 42 45 59 631/378/1689/364 64 692/617/375/365/1917/1285 82 82/29 Amyotrophic lateral sclerosis Animal models Biochemistry, Molecular Biology Cell cycle Cellular communication Cytology Degeneration Disease Frontotemporal dementia Genomics Humanities and Social Sciences Life Sciences Morphology multidisciplinary Neural networks Neural stem cells Neurobiology Neurodegeneration Neuronal-glial interactions Neurons Neurons and Cognition Neurotoxicity Pathology Pluripotency Proteins Science Science (multidisciplinary) Stem cells Transcriptomics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!