Gene-to-gene coordinated regulation of transcription and alternative splicing by 3D chromatin remodeling upon NF-κB activation

The NF-κB protein p65/RelA plays a pivotal role in coordinating gene expression in response to diverse stimuli, including viral infections. At the chromatin level, p65/RelA regulates gene transcription and alternative splicing through promoter enrichment and genomic exon occupancy, respectively. The...

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Veröffentlicht in:	Nucleic acids research 2024-02, Vol.52 (4), p.1527-1543
Hauptverfasser:	Marie, Paul, Bazire, Matéo, Ladet, Julien, Ameur, Lamya Ben, Chahar, Sanjay, Fontrodona, Nicolas, Sexton, Tom, Auboeuf, Didier, Bourgeois, Cyril F, Mortreux, Franck
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing - genetics Chromatin Assembly and Disassembly - genetics Gene Products, tax - genetics Gene Products, tax - metabolism Human T-lymphotropic virus 1 - genetics Human T-lymphotropic virus 1 - metabolism NAR Breakthrough NF-kappa B - genetics NF-kappa B - metabolism Signal Transduction Transcription Factor RelA - genetics Transcription Factor RelA - metabolism Transcriptional Activation
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