E-cadherin loss drives diffuse-type gastric tumorigenesis via EZH2-mediated reprogramming

Diffuse-type gastric adenocarcinoma (DGAC) is a deadly cancer often diagnosed late and resistant to treatment. While hereditary DGAC is linked to CDH1 mutations, the role of CDH1/E-cadherin inactivation in sporadic DGAC tumorigenesis remains elusive. We discovered CDH1 inactivation in a subset of DG...

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Veröffentlicht in:	The Journal of experimental medicine 2024-04, Vol.221 (4)
Hauptverfasser:	Zou, Gengyi, Huang, Yuanjian, Zhang, Shengzhe, Ko, Kyung-Pil, Kim, Bongjun, Zhang, Jie, Venkatesan, Vishwa, Pizzi, Melissa P, Fan, Yibo, Jun, Sohee, Niu, Na, Wang, Huamin, Song, Shumei, Ajani, Jaffer A, Park, Jae-Il
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ascites Cadherins - genetics Carcinogenesis - genetics Cell Transformation, Neoplastic Enhancer of Zeste Homolog 2 Protein - genetics Humans Mice Solid Tumors Stomach
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