Framework for in vivo T cell screens

In vivo T cell screens are a powerful tool for elucidating complex mechanisms of immunity, yet there is a lack of consensus on the screen design parameters required for robust in vivo screens: gene library size, cell transfer quantity, and number of mice. Here, we describe the Framework for In vivo...

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Veröffentlicht in:	The Journal of experimental medicine 2024-04, Vol.221 (4)
Hauptverfasser:	Milling, Lauren E, Markson, Samuel C, Tjokrosurjo, Qin, Derosia, Nicole M, Streeter, Ivy S L, Hickok, Grant H, Lemmen, Ashlyn M, Nguyen, Thao H, Prathima, Priyamvada, Fithian, William, Schwartz, Marc A, Hacohen, Nir, Doench, John G, LaFleur, Martin W, Sharpe, Arlene H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD8-Positive T-Lymphocytes Gene Knockout Techniques Lymphocyte Biology Mice Technical Advances and Resources Tumor immunology
Online-Zugang:	Volltext
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