Control of NAD+ homeostasis by autophagic flux modulates mitochondrial and cardiac function

Impaired autophagy is known to cause mitochondrial dysfunction and heart failure, in part due to altered mitophagy and protein quality control. However, whether additional mechanisms are involved in the development of mitochondrial dysfunction and heart failure in the setting of deficient autophagic...

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Veröffentlicht in:	The EMBO journal 2024-02, Vol.43 (3), p.362-390
Hauptverfasser:	Zhang, Quanjiang, Li, Zhonggang, Li, Qiuxia, Trammell, Samuel AJ, Schmidt, Mark S, Pires, Karla Maria, Cai, Jinjin, Zhang, Yuan, Kenny, Helena, Boudina, Sihem, Brenner, Charles, Abel, E Dale
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy Biomedical and Life Sciences EMBO04 EMBO07 EMBO21 Heart Failure Homeostasis Humans Life Sciences Mitochondrial Diseases NAD - metabolism NF-kappa B - metabolism Nicotinamide Mononucleotide Sequestosome-1 Protein - genetics
Online-Zugang:	Volltext
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