The causal relationship between psoriasis and chronic obstructive pulmonary disease: A bidirectional mendelian randomization study

Purpose Although many studies have investigated the association between psoriasis and chronic obstructive pulmonary disease (COPD), the causal relationship between psoriasis and COPD is still unknown. Methods We employed bidirectional Mendelian randomization to investigate the causal relationship be...

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Veröffentlicht in:	Skin research and technology 2024-03, Vol.30 (3), p.e13629-n/a
Hauptverfasser:	Liu, Meng, Zhou, Xiaolin, Zhang, Guanfei, Liu, Luyu, Fang, Chengyu, Li, Ziyan, Zheng, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	causality Chronic obstructive pulmonary disease COPD Genome-Wide Association Study Genomes Heterogeneity Humans Linkage disequilibrium Lung diseases mendelian randomization Mendelian Randomization Analysis Nucleotides Original Pleiotropy Psoriasis Psoriasis - epidemiology Psoriasis - genetics Pulmonary Disease, Chronic Obstructive - epidemiology Pulmonary Disease, Chronic Obstructive - genetics Randomization Reproducibility of Results Robustness (mathematics) Single-nucleotide polymorphism Skin diseases Statistical analysis
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Zusammenfassung:	Purpose Although many studies have investigated the association between psoriasis and chronic obstructive pulmonary disease (COPD), the causal relationship between psoriasis and COPD is still unknown. Methods We employed bidirectional Mendelian randomization to investigate the causal relationship between psoriasis and COPD. Genetic instruments for exposure were selected from two distinct genome‐wide association study databases. Single nucleotide polymorphisms associated with exposures at the genome‐wide significance level (p
ISSN:	0909-752X 1600-0846 1600-0846
DOI:	10.1111/srt.13629