Identification of C4BPA as biomarker associated with immune infiltration and prognosis in breast cancer

is a gene that encodes the C4BP protein α chain and is involved in the complement system. is regarded as a new biomarker for cancer, especially for non-small cell lung cancer and ovarian cancer. However, its role in breast cancer (BC) has not yet been determined. In this research, we used a bioinfor...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Translational cancer research 2024-01, Vol.13 (1), p.25-45
Hauptverfasser: Zou, Juan, Chen, Yaokun, Ji, Zeqi, Liu, Danyi, Chen, Xin, Chen, Mengjia, Chen, Kexun, Lin, Haojia, Chen, Yexi, Li, Zhiyang
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:is a gene that encodes the C4BP protein α chain and is involved in the complement system. is regarded as a new biomarker for cancer, especially for non-small cell lung cancer and ovarian cancer. However, its role in breast cancer (BC) has not yet been determined. In this research, we used a bioinformatics approach to assess the prognostic significance of C4BPA in BC. Utilizing a variety of databases and analysis tools, including The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), R, STRING, and the Kaplan-Meier plotter, we specifically assessed the connection between C4BPA and BC. expression was markedly decreased in BC tissues compared to its expression in normal breast tissues (P
ISSN:2218-676X
2219-6803
DOI:10.21037/tcr-23-1215