Association between CNR1 gene polymorphisms and susceptibility to diabetic nephropathy in Iraqi patients with T2DM
In individuals with type 2 diabetes mellitus (T2DM), the cannabinoid receptor 1 ( ) gene polymorphism has been linked to diabetic nephropathy (DN). Different renal disorders, including DN, have been found to alter cannabinoid (CB) receptor expression and activation. This cross-sectional study aimed...
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| description | In individuals with type 2 diabetes mellitus (T2DM), the cannabinoid receptor 1 (
) gene polymorphism has been linked to diabetic nephropathy (DN). Different renal disorders, including DN, have been found to alter cannabinoid (CB) receptor expression and activation. This cross-sectional study aimed to investigate the relationship between
rs1776966256 and rs1243008337 genetic variants and the risk of developing DN in Iraqi patients with T2DM. The study included 100 patients with T2DM, divided into two groups: 50 with DN and 50 without DN. Genotyping of
rs1776966256 and rs1243008337 polymorphisms was conducted using PCR in DN patients and control samples. The distribution of rs1776966256 and rs1243008337 genotypes and alleles between the two groups revealed statistically significant differences. The frequencies of the GG and AG genotypes of
rs1776966256 were significantly different between DN patients and the control group. Additionally, compared to the A allele, the G allele of this polymorphism was linked to a higher incidence of DN (p=0.0001). Patients with the genetic polymorphism rs1243008337 had higher genotypes of CC and AC and were more likely to develop DN in the polymorphism genotype than the wild genotype. Additionally, compared to the A allele, the C allele was linked to a higher chance of developing DN (p=0.0001). Both rs1776966256 and rs1243008337 polymorphisms were correlated with the development of diabetic nephropathy. |
| doi_str_mv | 10.25122/jml-2023-0181 |
| format | Article |
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) gene polymorphism has been linked to diabetic nephropathy (DN). Different renal disorders, including DN, have been found to alter cannabinoid (CB) receptor expression and activation. This cross-sectional study aimed to investigate the relationship between
rs1776966256 and rs1243008337 genetic variants and the risk of developing DN in Iraqi patients with T2DM. The study included 100 patients with T2DM, divided into two groups: 50 with DN and 50 without DN. Genotyping of
rs1776966256 and rs1243008337 polymorphisms was conducted using PCR in DN patients and control samples. The distribution of rs1776966256 and rs1243008337 genotypes and alleles between the two groups revealed statistically significant differences. The frequencies of the GG and AG genotypes of
rs1776966256 were significantly different between DN patients and the control group. Additionally, compared to the A allele, the G allele of this polymorphism was linked to a higher incidence of DN (p=0.0001). Patients with the genetic polymorphism rs1243008337 had higher genotypes of CC and AC and were more likely to develop DN in the polymorphism genotype than the wild genotype. Additionally, compared to the A allele, the C allele was linked to a higher chance of developing DN (p=0.0001). Both rs1776966256 and rs1243008337 polymorphisms were correlated with the development of diabetic nephropathy.</description><identifier>ISSN: 1844-3117</identifier><identifier>ISSN: 1844-122X</identifier><identifier>EISSN: 1844-3117</identifier><identifier>DOI: 10.25122/jml-2023-0181</identifier><identifier>PMID: 38406790</identifier><language>eng</language><publisher>Romania: Carol Daila University Foundation</publisher><subject>Body mass index ; Case-Control Studies ; Creatinine ; Cross-Sectional Studies ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - genetics ; Diabetic Nephropathies - epidemiology ; Diabetic Nephropathies - genetics ; Diabetic nephropathy ; Disease ; Gene Frequency - genetics ; Gene polymorphism ; Genetic Predisposition to Disease - genetics ; Genetic testing ; Genotype ; Genotype & phenotype ; Humans ; Iraq ; Kidneys ; Kinases ; Nephropathy ; Original ; Patients ; Polymorphism ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide - genetics ; Proteins ; Receptor, Cannabinoid, CB1 - genetics ; Statistical analysis ; Urine ; Variance analysis</subject><ispartof>Journal of medicine and life, 2023-11, Vol.16 (11), p.1663-1669</ispartof><rights>2023 The Author(s).</rights><rights>Copyright Carol Daila University Foundation Nov 2023</rights><rights>2023 The Author(s) 2023</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2891-a4596307a2e5af672b47396c78c1a9f6635a8a5d30910f46173710c5db367123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10893564/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10893564/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38406790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aljorani, Raghda Hisham</creatorcontrib><creatorcontrib>Saleh, Eman Saadi</creatorcontrib><creatorcontrib>Al Mohammadawi, Khalaf Gata</creatorcontrib><creatorcontrib>Department of Clinical Laboratory Sciences, Faculty of Pharmacy, Al-Rafidain University College, Baghdad, Iraq</creatorcontrib><creatorcontrib>Department of Clinical Laboratory Sciences, College of Pharmacy, University of Baghdad, Baghdad, Iraq</creatorcontrib><creatorcontrib>Specialized Center for Endocrinology and Diabetes, Baghdad, Iraq</creatorcontrib><title>Association between CNR1 gene polymorphisms and susceptibility to diabetic nephropathy in Iraqi patients with T2DM</title><title>Journal of medicine and life</title><addtitle>J Med Life</addtitle><description>In individuals with type 2 diabetes mellitus (T2DM), the cannabinoid receptor 1 (
) gene polymorphism has been linked to diabetic nephropathy (DN). Different renal disorders, including DN, have been found to alter cannabinoid (CB) receptor expression and activation. This cross-sectional study aimed to investigate the relationship between
rs1776966256 and rs1243008337 genetic variants and the risk of developing DN in Iraqi patients with T2DM. The study included 100 patients with T2DM, divided into two groups: 50 with DN and 50 without DN. Genotyping of
rs1776966256 and rs1243008337 polymorphisms was conducted using PCR in DN patients and control samples. The distribution of rs1776966256 and rs1243008337 genotypes and alleles between the two groups revealed statistically significant differences. The frequencies of the GG and AG genotypes of
rs1776966256 were significantly different between DN patients and the control group. Additionally, compared to the A allele, the G allele of this polymorphism was linked to a higher incidence of DN (p=0.0001). Patients with the genetic polymorphism rs1243008337 had higher genotypes of CC and AC and were more likely to develop DN in the polymorphism genotype than the wild genotype. Additionally, compared to the A allele, the C allele was linked to a higher chance of developing DN (p=0.0001). Both rs1776966256 and rs1243008337 polymorphisms were correlated with the development of diabetic nephropathy.</description><subject>Body mass index</subject><subject>Case-Control Studies</subject><subject>Creatinine</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetic Nephropathies - epidemiology</subject><subject>Diabetic Nephropathies - genetics</subject><subject>Diabetic nephropathy</subject><subject>Disease</subject><subject>Gene Frequency - genetics</subject><subject>Gene polymorphism</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genetic testing</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Iraq</subject><subject>Kidneys</subject><subject>Kinases</subject><subject>Nephropathy</subject><subject>Original</subject><subject>Patients</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Proteins</subject><subject>Receptor, Cannabinoid, CB1 - genetics</subject><subject>Statistical analysis</subject><subject>Urine</subject><subject>Variance analysis</subject><issn>1844-3117</issn><issn>1844-122X</issn><issn>1844-3117</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkc1rFTEUxYNYbKndupSAGzfT5juTlZRn1UKtIG8fMplMJ4-ZZJpkLO-_b2o_qGZzE-65h3vyA-ADRqeEY0LOdvPUEERog3CL34Aj3DLWUIzl21f3Q3CS8w7Vw7gQgr4Dh7RlSEiFjkA6zzlab4qPAXau3DkX4Ob6N4Y3Lji4xGk_x7SMPs8ZmtDDvGbrluI7P_myhyXC3ps66C0MbhlTXEwZ99AHeJnMrYf16V0oGd75MsIt-frzPTgYzJTdyVM9BttvF9vNj-bq1_fLzflVY0mrcGMYV4IiaYjjZhCSdExSJaxsLTZqqEG4aQ3vKVIYDUxgSSVGlvcdFRITegy-PNouaze73tYlkpn0kvxs0l5H4_W_neBHfRP_aIxaRblg1eHzk0OKt6vLRc--hp8mE1xcsyaK1s_HQrVV-uk_6S6uKdR4miLOCEZK8Ko6fVTZFHNObnjZBiP9l6iuRPUDUf1AtA58fJ3hRf7Mj94Dr3ucTA</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Aljorani, Raghda Hisham</creator><creator>Saleh, Eman Saadi</creator><creator>Al Mohammadawi, Khalaf Gata</creator><general>Carol Daila University Foundation</general><general>Carol Davila University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20231101</creationdate><title>Association between CNR1 gene polymorphisms and susceptibility to diabetic nephropathy in Iraqi patients with T2DM</title><author>Aljorani, Raghda Hisham ; Saleh, Eman Saadi ; Al Mohammadawi, Khalaf Gata</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2891-a4596307a2e5af672b47396c78c1a9f6635a8a5d30910f46173710c5db367123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Body mass index</topic><topic>Case-Control Studies</topic><topic>Creatinine</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetic Nephropathies - epidemiology</topic><topic>Diabetic Nephropathies - genetics</topic><topic>Diabetic nephropathy</topic><topic>Disease</topic><topic>Gene Frequency - genetics</topic><topic>Gene polymorphism</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genetic testing</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>Iraq</topic><topic>Kidneys</topic><topic>Kinases</topic><topic>Nephropathy</topic><topic>Original</topic><topic>Patients</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Proteins</topic><topic>Receptor, Cannabinoid, CB1 - genetics</topic><topic>Statistical analysis</topic><topic>Urine</topic><topic>Variance analysis</topic><toplevel>online_resources</toplevel><creatorcontrib>Aljorani, Raghda Hisham</creatorcontrib><creatorcontrib>Saleh, Eman Saadi</creatorcontrib><creatorcontrib>Al Mohammadawi, Khalaf Gata</creatorcontrib><creatorcontrib>Department of Clinical Laboratory Sciences, Faculty of Pharmacy, Al-Rafidain University College, Baghdad, Iraq</creatorcontrib><creatorcontrib>Department of Clinical Laboratory Sciences, College of Pharmacy, University of Baghdad, Baghdad, Iraq</creatorcontrib><creatorcontrib>Specialized Center for Endocrinology and Diabetes, Baghdad, Iraq</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of medicine and life</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aljorani, Raghda Hisham</au><au>Saleh, Eman Saadi</au><au>Al Mohammadawi, Khalaf Gata</au><aucorp>Department of Clinical Laboratory Sciences, Faculty of Pharmacy, Al-Rafidain University College, Baghdad, Iraq</aucorp><aucorp>Department of Clinical Laboratory Sciences, College of Pharmacy, University of Baghdad, Baghdad, Iraq</aucorp><aucorp>Specialized Center for Endocrinology and Diabetes, Baghdad, Iraq</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between CNR1 gene polymorphisms and susceptibility to diabetic nephropathy in Iraqi patients with T2DM</atitle><jtitle>Journal of medicine and life</jtitle><addtitle>J Med Life</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>16</volume><issue>11</issue><spage>1663</spage><epage>1669</epage><pages>1663-1669</pages><issn>1844-3117</issn><issn>1844-122X</issn><eissn>1844-3117</eissn><abstract>In individuals with type 2 diabetes mellitus (T2DM), the cannabinoid receptor 1 (
) gene polymorphism has been linked to diabetic nephropathy (DN). Different renal disorders, including DN, have been found to alter cannabinoid (CB) receptor expression and activation. This cross-sectional study aimed to investigate the relationship between
rs1776966256 and rs1243008337 genetic variants and the risk of developing DN in Iraqi patients with T2DM. The study included 100 patients with T2DM, divided into two groups: 50 with DN and 50 without DN. Genotyping of
rs1776966256 and rs1243008337 polymorphisms was conducted using PCR in DN patients and control samples. The distribution of rs1776966256 and rs1243008337 genotypes and alleles between the two groups revealed statistically significant differences. The frequencies of the GG and AG genotypes of
rs1776966256 were significantly different between DN patients and the control group. Additionally, compared to the A allele, the G allele of this polymorphism was linked to a higher incidence of DN (p=0.0001). Patients with the genetic polymorphism rs1243008337 had higher genotypes of CC and AC and were more likely to develop DN in the polymorphism genotype than the wild genotype. Additionally, compared to the A allele, the C allele was linked to a higher chance of developing DN (p=0.0001). Both rs1776966256 and rs1243008337 polymorphisms were correlated with the development of diabetic nephropathy.</abstract><cop>Romania</cop><pub>Carol Daila University Foundation</pub><pmid>38406790</pmid><doi>10.25122/jml-2023-0181</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Body mass index Case-Control Studies Creatinine Cross-Sectional Studies Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics Diabetic Nephropathies - epidemiology Diabetic Nephropathies - genetics Diabetic nephropathy Disease Gene Frequency - genetics Gene polymorphism Genetic Predisposition to Disease - genetics Genetic testing Genotype Genotype & phenotype Humans Iraq Kidneys Kinases Nephropathy Original Patients Polymorphism Polymorphism, Genetic Polymorphism, Single Nucleotide - genetics Proteins Receptor, Cannabinoid, CB1 - genetics Statistical analysis Urine Variance analysis |
| title | Association between CNR1 gene polymorphisms and susceptibility to diabetic nephropathy in Iraqi patients with T2DM |
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