Head-to-head comparison of [11C]methionine PET, [11C]choline PET, and 4-dimensional CT as second-line scans for detection of parathyroid adenomas in primary hyperparathyroidism
Purpose Accurate preoperative localization is imperative to guide surgery in primary hyperparathyroidism (pHPT). It remains unclear which second-line imaging technique is most effective after negative first-line imaging. In this study, we compare the diagnostic effectiveness of [ 11 C]methionine PET...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2024-03, Vol.51 (4), p.1050-1059 |
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| creator | Noltes, Milou E. Kruijff, Schelto Appelman, Auke P. A. Jansen, Liesbeth Zandee, Wouter T. Links, Thera P. van Hemel, Bettien M. Schouw, Hugo M. Dierckx, Rudi A. J. O. Francken, Anne Brecht Kelder, Wendy van der Hoorn, Anouk Brouwers, Adrienne H. |
| description | Purpose
Accurate preoperative localization is imperative to guide surgery in primary hyperparathyroidism (pHPT). It remains unclear which second-line imaging technique is most effective after negative first-line imaging. In this study, we compare the diagnostic effectiveness of [
11
C]methionine PET/CT, [
11
C]choline PET/CT, and four dimensional (4D)-CT head-to-head in patients with pHPT, to explore which of these imaging techniques to use as a second-line scan.
Methods
We conducted a powered, prospective, blinded cohort study in patients with biochemically proven pHPT and prior negative or discordant first-line imaging consisting of ultrasonography and
99m
Tc-sestamibi. All patients underwent [
11
C]methionine PET/CT, [
11
C]choline PET/CT, and 4D-CT. At first, all scans were interpreted by a nuclear medicine physician, and a radiologist who were blinded from patient data and all imaging results. Next, a non-blinded scan reading was performed. The scan results were correlated with surgical and histopathological findings. Serum calcium values at least 6 months after surgery were used as gold standard for curation of HPT.
Results
A total of 32 patients were included in the study. With blinded evaluation, [
11
C]choline PET/CT was positive in 28 patients (88%), [
11
C]methionine PET/CT in 23 (72%), and 4D-CT in 15 patients (47%), respectively. In total, 30 patients have undergone surgery and 32 parathyroid lesions were histologically confirmed as parathyroid adenomas. Based on the blinded evaluation, lesion-based sensitivity of [
11
C]choline PET/CT, [
11
C]methionine PET/CT, and 4D-CT was respectively 85%, 67%, and 39%. The sensitivity of [
11
C]choline PET/CT differed significantly from that of [
11
C]methionine PET/CT and 4D-CT (
p
= 0.031 and
p
|
| doi_str_mv | 10.1007/s00259-023-06488-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10881780</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2929305093</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-18909333fe042465d800f2a73ab4f1d668e56063b3b2d8c839952145552176473</originalsourceid><addsrcrecordid>eNp9ks9vFCEUx4mxsXX1H_BgSLx4kMqPYYCTaTbVmjRpD-vJGMIC06GZgRVmTfa_8k-U7axr9eCFR3gfvo_H-wLwiuBzgrF4XzCmXCFMGcJtIyUST8AZaYlCAkv19LgX-BQ8L-UeYyKpVM_AKRNKcCnFGfh55Y1DU0J9jdCmcWNyKCnC1MGvhCy_jX7qQ4ohenh7uXo3H9o-DccTEx1skAujj6WSZoDLFTQFFm9TdOgBLNbEAruUofOTt1OYK9RiZup3OQUHjfMxjfVeiHCTw2jyDva7jc-PoFDGF-CkM0PxLw9xAb58vFwtr9D1zafPy4trZBvaTohIhRVjrPO4oU3LncS4o0Yws2464tpWet7ilq3ZmjppJVOKU9JwXlfRNoItwIdZd7Ndj95ZH6dsBn14mU4m6L8zMfT6Lv3QBEtJhMRV4e1BIafvW18mPYZi_TCY6NO26DoKIjivk6zom3_Q-7TN9SsrpahimO-bWQA6UzanUrLvjq8hWO8doWdH6OoI_eAIvZd-_biP45XfFqgAm4FSU_HO5z-1_yP7C7xhwhA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2929305093</pqid></control><display><type>article</type><title>Head-to-head comparison of [11C]methionine PET, [11C]choline PET, and 4-dimensional CT as second-line scans for detection of parathyroid adenomas in primary hyperparathyroidism</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Noltes, Milou E. ; Kruijff, Schelto ; Appelman, Auke P. A. ; Jansen, Liesbeth ; Zandee, Wouter T. ; Links, Thera P. ; van Hemel, Bettien M. ; Schouw, Hugo M. ; Dierckx, Rudi A. J. O. ; Francken, Anne Brecht ; Kelder, Wendy ; van der Hoorn, Anouk ; Brouwers, Adrienne H.</creator><creatorcontrib>Noltes, Milou E. ; Kruijff, Schelto ; Appelman, Auke P. A. ; Jansen, Liesbeth ; Zandee, Wouter T. ; Links, Thera P. ; van Hemel, Bettien M. ; Schouw, Hugo M. ; Dierckx, Rudi A. J. O. ; Francken, Anne Brecht ; Kelder, Wendy ; van der Hoorn, Anouk ; Brouwers, Adrienne H.</creatorcontrib><description>Purpose
Accurate preoperative localization is imperative to guide surgery in primary hyperparathyroidism (pHPT). It remains unclear which second-line imaging technique is most effective after negative first-line imaging. In this study, we compare the diagnostic effectiveness of [
11
C]methionine PET/CT, [
11
C]choline PET/CT, and four dimensional (4D)-CT head-to-head in patients with pHPT, to explore which of these imaging techniques to use as a second-line scan.
Methods
We conducted a powered, prospective, blinded cohort study in patients with biochemically proven pHPT and prior negative or discordant first-line imaging consisting of ultrasonography and
99m
Tc-sestamibi. All patients underwent [
11
C]methionine PET/CT, [
11
C]choline PET/CT, and 4D-CT. At first, all scans were interpreted by a nuclear medicine physician, and a radiologist who were blinded from patient data and all imaging results. Next, a non-blinded scan reading was performed. The scan results were correlated with surgical and histopathological findings. Serum calcium values at least 6 months after surgery were used as gold standard for curation of HPT.
Results
A total of 32 patients were included in the study. With blinded evaluation, [
11
C]choline PET/CT was positive in 28 patients (88%), [
11
C]methionine PET/CT in 23 (72%), and 4D-CT in 15 patients (47%), respectively. In total, 30 patients have undergone surgery and 32 parathyroid lesions were histologically confirmed as parathyroid adenomas. Based on the blinded evaluation, lesion-based sensitivity of [
11
C]choline PET/CT, [
11
C]methionine PET/CT, and 4D-CT was respectively 85%, 67%, and 39%. The sensitivity of [
11
C]choline PET/CT differed significantly from that of [
11
C]methionine PET/CT and 4D-CT (
p
= 0.031 and
p
< 0.0005, respectively).
Conclusion
In the setting of pHPT with negative first-line imaging, [
11
C]choline PET/CT is superior to [
11
C]methionine PET/CT and 4D-CT in localizing parathyroid adenomas, allowing correct localization in 85% of adenomas. Further studies are needed to determine cost–benefit and efficacy of these scans, including the timing of these scans as first- or second-line imaging techniques.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-023-06488-7</identifier><identifier>PMID: 37975887</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adenoma ; Calcium (blood) ; Cardiology ; Choline ; Cohort Studies ; Computed tomography ; Humans ; Hyperparathyroidism ; Hyperparathyroidism, Primary - diagnostic imaging ; Hyperparathyroidism, Primary - surgery ; Imaging ; Imaging techniques ; Lesions ; Localization ; Medical imaging ; Medicine ; Medicine & Public Health ; Methionine ; Nuclear Medicine ; Oncology ; Original ; Original Article ; Orthopedics ; Parathyroid ; Parathyroid Glands ; Parathyroid Neoplasms - complications ; Parathyroid Neoplasms - diagnostic imaging ; Patients ; Positron emission ; Positron Emission Tomography Computed Tomography - methods ; Prospective Studies ; Racemethionine ; Radiology ; Sensitivity analysis ; Surgery ; Technetium Tc 99m Sestamibi ; Tumors</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2024-03, Vol.51 (4), p.1050-1059</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c426t-18909333fe042465d800f2a73ab4f1d668e56063b3b2d8c839952145552176473</cites><orcidid>0000-0003-2698-1516</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00259-023-06488-7$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00259-023-06488-7$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37975887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Noltes, Milou E.</creatorcontrib><creatorcontrib>Kruijff, Schelto</creatorcontrib><creatorcontrib>Appelman, Auke P. A.</creatorcontrib><creatorcontrib>Jansen, Liesbeth</creatorcontrib><creatorcontrib>Zandee, Wouter T.</creatorcontrib><creatorcontrib>Links, Thera P.</creatorcontrib><creatorcontrib>van Hemel, Bettien M.</creatorcontrib><creatorcontrib>Schouw, Hugo M.</creatorcontrib><creatorcontrib>Dierckx, Rudi A. J. O.</creatorcontrib><creatorcontrib>Francken, Anne Brecht</creatorcontrib><creatorcontrib>Kelder, Wendy</creatorcontrib><creatorcontrib>van der Hoorn, Anouk</creatorcontrib><creatorcontrib>Brouwers, Adrienne H.</creatorcontrib><title>Head-to-head comparison of [11C]methionine PET, [11C]choline PET, and 4-dimensional CT as second-line scans for detection of parathyroid adenomas in primary hyperparathyroidism</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Purpose
Accurate preoperative localization is imperative to guide surgery in primary hyperparathyroidism (pHPT). It remains unclear which second-line imaging technique is most effective after negative first-line imaging. In this study, we compare the diagnostic effectiveness of [
11
C]methionine PET/CT, [
11
C]choline PET/CT, and four dimensional (4D)-CT head-to-head in patients with pHPT, to explore which of these imaging techniques to use as a second-line scan.
Methods
We conducted a powered, prospective, blinded cohort study in patients with biochemically proven pHPT and prior negative or discordant first-line imaging consisting of ultrasonography and
99m
Tc-sestamibi. All patients underwent [
11
C]methionine PET/CT, [
11
C]choline PET/CT, and 4D-CT. At first, all scans were interpreted by a nuclear medicine physician, and a radiologist who were blinded from patient data and all imaging results. Next, a non-blinded scan reading was performed. The scan results were correlated with surgical and histopathological findings. Serum calcium values at least 6 months after surgery were used as gold standard for curation of HPT.
Results
A total of 32 patients were included in the study. With blinded evaluation, [
11
C]choline PET/CT was positive in 28 patients (88%), [
11
C]methionine PET/CT in 23 (72%), and 4D-CT in 15 patients (47%), respectively. In total, 30 patients have undergone surgery and 32 parathyroid lesions were histologically confirmed as parathyroid adenomas. Based on the blinded evaluation, lesion-based sensitivity of [
11
C]choline PET/CT, [
11
C]methionine PET/CT, and 4D-CT was respectively 85%, 67%, and 39%. The sensitivity of [
11
C]choline PET/CT differed significantly from that of [
11
C]methionine PET/CT and 4D-CT (
p
= 0.031 and
p
< 0.0005, respectively).
Conclusion
In the setting of pHPT with negative first-line imaging, [
11
C]choline PET/CT is superior to [
11
C]methionine PET/CT and 4D-CT in localizing parathyroid adenomas, allowing correct localization in 85% of adenomas. Further studies are needed to determine cost–benefit and efficacy of these scans, including the timing of these scans as first- or second-line imaging techniques.</description><subject>Adenoma</subject><subject>Calcium (blood)</subject><subject>Cardiology</subject><subject>Choline</subject><subject>Cohort Studies</subject><subject>Computed tomography</subject><subject>Humans</subject><subject>Hyperparathyroidism</subject><subject>Hyperparathyroidism, Primary - diagnostic imaging</subject><subject>Hyperparathyroidism, Primary - surgery</subject><subject>Imaging</subject><subject>Imaging techniques</subject><subject>Lesions</subject><subject>Localization</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methionine</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Original</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Parathyroid</subject><subject>Parathyroid Glands</subject><subject>Parathyroid Neoplasms - complications</subject><subject>Parathyroid Neoplasms - diagnostic imaging</subject><subject>Patients</subject><subject>Positron emission</subject><subject>Positron Emission Tomography Computed Tomography - methods</subject><subject>Prospective Studies</subject><subject>Racemethionine</subject><subject>Radiology</subject><subject>Sensitivity analysis</subject><subject>Surgery</subject><subject>Technetium Tc 99m Sestamibi</subject><subject>Tumors</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9ks9vFCEUx4mxsXX1H_BgSLx4kMqPYYCTaTbVmjRpD-vJGMIC06GZgRVmTfa_8k-U7axr9eCFR3gfvo_H-wLwiuBzgrF4XzCmXCFMGcJtIyUST8AZaYlCAkv19LgX-BQ8L-UeYyKpVM_AKRNKcCnFGfh55Y1DU0J9jdCmcWNyKCnC1MGvhCy_jX7qQ4ohenh7uXo3H9o-DccTEx1skAujj6WSZoDLFTQFFm9TdOgBLNbEAruUofOTt1OYK9RiZup3OQUHjfMxjfVeiHCTw2jyDva7jc-PoFDGF-CkM0PxLw9xAb58vFwtr9D1zafPy4trZBvaTohIhRVjrPO4oU3LncS4o0Yws2464tpWet7ilq3ZmjppJVOKU9JwXlfRNoItwIdZd7Ndj95ZH6dsBn14mU4m6L8zMfT6Lv3QBEtJhMRV4e1BIafvW18mPYZi_TCY6NO26DoKIjivk6zom3_Q-7TN9SsrpahimO-bWQA6UzanUrLvjq8hWO8doWdH6OoI_eAIvZd-_biP45XfFqgAm4FSU_HO5z-1_yP7C7xhwhA</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Noltes, Milou E.</creator><creator>Kruijff, Schelto</creator><creator>Appelman, Auke P. A.</creator><creator>Jansen, Liesbeth</creator><creator>Zandee, Wouter T.</creator><creator>Links, Thera P.</creator><creator>van Hemel, Bettien M.</creator><creator>Schouw, Hugo M.</creator><creator>Dierckx, Rudi A. J. O.</creator><creator>Francken, Anne Brecht</creator><creator>Kelder, Wendy</creator><creator>van der Hoorn, Anouk</creator><creator>Brouwers, Adrienne H.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2698-1516</orcidid></search><sort><creationdate>20240301</creationdate><title>Head-to-head comparison of [11C]methionine PET, [11C]choline PET, and 4-dimensional CT as second-line scans for detection of parathyroid adenomas in primary hyperparathyroidism</title><author>Noltes, Milou E. ; Kruijff, Schelto ; Appelman, Auke P. A. ; Jansen, Liesbeth ; Zandee, Wouter T. ; Links, Thera P. ; van Hemel, Bettien M. ; Schouw, Hugo M. ; Dierckx, Rudi A. J. O. ; Francken, Anne Brecht ; Kelder, Wendy ; van der Hoorn, Anouk ; Brouwers, Adrienne H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-18909333fe042465d800f2a73ab4f1d668e56063b3b2d8c839952145552176473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adenoma</topic><topic>Calcium (blood)</topic><topic>Cardiology</topic><topic>Choline</topic><topic>Cohort Studies</topic><topic>Computed tomography</topic><topic>Humans</topic><topic>Hyperparathyroidism</topic><topic>Hyperparathyroidism, Primary - diagnostic imaging</topic><topic>Hyperparathyroidism, Primary - surgery</topic><topic>Imaging</topic><topic>Imaging techniques</topic><topic>Lesions</topic><topic>Localization</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methionine</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Original</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Parathyroid</topic><topic>Parathyroid Glands</topic><topic>Parathyroid Neoplasms - complications</topic><topic>Parathyroid Neoplasms - diagnostic imaging</topic><topic>Patients</topic><topic>Positron emission</topic><topic>Positron Emission Tomography Computed Tomography - methods</topic><topic>Prospective Studies</topic><topic>Racemethionine</topic><topic>Radiology</topic><topic>Sensitivity analysis</topic><topic>Surgery</topic><topic>Technetium Tc 99m Sestamibi</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Noltes, Milou E.</creatorcontrib><creatorcontrib>Kruijff, Schelto</creatorcontrib><creatorcontrib>Appelman, Auke P. A.</creatorcontrib><creatorcontrib>Jansen, Liesbeth</creatorcontrib><creatorcontrib>Zandee, Wouter T.</creatorcontrib><creatorcontrib>Links, Thera P.</creatorcontrib><creatorcontrib>van Hemel, Bettien M.</creatorcontrib><creatorcontrib>Schouw, Hugo M.</creatorcontrib><creatorcontrib>Dierckx, Rudi A. J. O.</creatorcontrib><creatorcontrib>Francken, Anne Brecht</creatorcontrib><creatorcontrib>Kelder, Wendy</creatorcontrib><creatorcontrib>van der Hoorn, Anouk</creatorcontrib><creatorcontrib>Brouwers, Adrienne H.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Noltes, Milou E.</au><au>Kruijff, Schelto</au><au>Appelman, Auke P. A.</au><au>Jansen, Liesbeth</au><au>Zandee, Wouter T.</au><au>Links, Thera P.</au><au>van Hemel, Bettien M.</au><au>Schouw, Hugo M.</au><au>Dierckx, Rudi A. J. O.</au><au>Francken, Anne Brecht</au><au>Kelder, Wendy</au><au>van der Hoorn, Anouk</au><au>Brouwers, Adrienne H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Head-to-head comparison of [11C]methionine PET, [11C]choline PET, and 4-dimensional CT as second-line scans for detection of parathyroid adenomas in primary hyperparathyroidism</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><stitle>Eur J Nucl Med Mol Imaging</stitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2024-03-01</date><risdate>2024</risdate><volume>51</volume><issue>4</issue><spage>1050</spage><epage>1059</epage><pages>1050-1059</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Purpose
Accurate preoperative localization is imperative to guide surgery in primary hyperparathyroidism (pHPT). It remains unclear which second-line imaging technique is most effective after negative first-line imaging. In this study, we compare the diagnostic effectiveness of [
11
C]methionine PET/CT, [
11
C]choline PET/CT, and four dimensional (4D)-CT head-to-head in patients with pHPT, to explore which of these imaging techniques to use as a second-line scan.
Methods
We conducted a powered, prospective, blinded cohort study in patients with biochemically proven pHPT and prior negative or discordant first-line imaging consisting of ultrasonography and
99m
Tc-sestamibi. All patients underwent [
11
C]methionine PET/CT, [
11
C]choline PET/CT, and 4D-CT. At first, all scans were interpreted by a nuclear medicine physician, and a radiologist who were blinded from patient data and all imaging results. Next, a non-blinded scan reading was performed. The scan results were correlated with surgical and histopathological findings. Serum calcium values at least 6 months after surgery were used as gold standard for curation of HPT.
Results
A total of 32 patients were included in the study. With blinded evaluation, [
11
C]choline PET/CT was positive in 28 patients (88%), [
11
C]methionine PET/CT in 23 (72%), and 4D-CT in 15 patients (47%), respectively. In total, 30 patients have undergone surgery and 32 parathyroid lesions were histologically confirmed as parathyroid adenomas. Based on the blinded evaluation, lesion-based sensitivity of [
11
C]choline PET/CT, [
11
C]methionine PET/CT, and 4D-CT was respectively 85%, 67%, and 39%. The sensitivity of [
11
C]choline PET/CT differed significantly from that of [
11
C]methionine PET/CT and 4D-CT (
p
= 0.031 and
p
< 0.0005, respectively).
Conclusion
In the setting of pHPT with negative first-line imaging, [
11
C]choline PET/CT is superior to [
11
C]methionine PET/CT and 4D-CT in localizing parathyroid adenomas, allowing correct localization in 85% of adenomas. Further studies are needed to determine cost–benefit and efficacy of these scans, including the timing of these scans as first- or second-line imaging techniques.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37975887</pmid><doi>10.1007/s00259-023-06488-7</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-2698-1516</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1619-7070 |
| ispartof | European journal of nuclear medicine and molecular imaging, 2024-03, Vol.51 (4), p.1050-1059 |
| issn | 1619-7070 1619-7089 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10881780 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adenoma Calcium (blood) Cardiology Choline Cohort Studies Computed tomography Humans Hyperparathyroidism Hyperparathyroidism, Primary - diagnostic imaging Hyperparathyroidism, Primary - surgery Imaging Imaging techniques Lesions Localization Medical imaging Medicine Medicine & Public Health Methionine Nuclear Medicine Oncology Original Original Article Orthopedics Parathyroid Parathyroid Glands Parathyroid Neoplasms - complications Parathyroid Neoplasms - diagnostic imaging Patients Positron emission Positron Emission Tomography Computed Tomography - methods Prospective Studies Racemethionine Radiology Sensitivity analysis Surgery Technetium Tc 99m Sestamibi Tumors |
| title | Head-to-head comparison of [11C]methionine PET, [11C]choline PET, and 4-dimensional CT as second-line scans for detection of parathyroid adenomas in primary hyperparathyroidism |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T18%3A20%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Head-to-head%20comparison%20of%20%5B11C%5Dmethionine%20PET,%20%5B11C%5Dcholine%20PET,%20and%204-dimensional%20CT%20as%20second-line%20scans%20for%20detection%20of%20parathyroid%20adenomas%20in%20primary%20hyperparathyroidism&rft.jtitle=European%20journal%20of%20nuclear%20medicine%20and%20molecular%20imaging&rft.au=Noltes,%20Milou%20E.&rft.date=2024-03-01&rft.volume=51&rft.issue=4&rft.spage=1050&rft.epage=1059&rft.pages=1050-1059&rft.issn=1619-7070&rft.eissn=1619-7089&rft_id=info:doi/10.1007/s00259-023-06488-7&rft_dat=%3Cproquest_pubme%3E2929305093%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2929305093&rft_id=info:pmid/37975887&rfr_iscdi=true |