Human nuclear hormone receptor activity contributes to malaria parasite liver stage development

Chemical genetic approaches have had a transformative impact on discovery of drug targets for malaria but have primarily been used for parasite targets. To identify human pathways required for intrahepatic development of parasite, we implemented multiplex cytological profiling of malaria infected he...

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Veröffentlicht in:	Cell chemical biology 2023-05, Vol.30 (5), p.486-498.e7
Hauptverfasser:	Mittal, Nimisha, Davis, Chadwick, McLean, Peter, Calla, Jaeson, Godinez-Macias, Karla P., Gardner, Alison, Healey, David, Orjuela-Sanchez, Pamela, Ottilie, Sabine, Chong, Yolanda, Gibson, Christopher, Winzeler, Elizabeth A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals drug discovery Hepatocytes - metabolism Humans Liver - metabolism malaria Malaria - drug therapy Malaria - metabolism nuclear hormone receptors Parasites phenotypic screening Plasmodium Plasmodium berghei - genetics siRNA
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