Combining Surface-Induced Dissociation and Charge Detection Mass Spectrometry to Reveal the Native Topology of Heterogeneous Protein Complexes

Charge detection mass spectrometry (CDMS) enables the direct mass measurement of heterogeneous samples on the megadalton scale, as the charge state for a single ion is determined simultaneously with the mass-to-charge ratio (m/z). Surface-induced dissociation (SID) is an effective activation method...

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Veröffentlicht in:	Analytical chemistry (Washington) 2023-09, Vol.95 (37), p.13889-13896
Hauptverfasser:	Du, Chen, Cleary, Sean P., Kostelic, Marius M., Jones, Benjamin J., Kafader, Jared O., Wysocki, Vicki H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Assemblies Capsid Capsids Chemistry Dependovirus Macromolecules Mass Spectrometry Mass spectroscopy Proteins Software Topology Trimers Viruses
Online-Zugang:	Volltext
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