PCDH8 is a novel prognostic biomarker in thyroid cancer and promotes cell proliferation and viability
Protocadherin 8 (PCDH8), a calcium-dependent transmembrane protein in the protocadherin family, regulates cell adhesion and signal transduction. While some studies have provided indirect evidence that PCDH8 has cancer-promoting properties, this association is controversial. In particular, its involv...
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| creator | Yang, Ruida Yang, Nan Yin, Pan Xue, Zihan Sun, Feidi Fan, Ruihan Liang, JiaFu Lv, Xinru Wu, Shaobo Sun, Liankang |
| description | Protocadherin 8 (PCDH8), a calcium-dependent transmembrane protein in the protocadherin family, regulates cell adhesion and signal transduction. While some studies have provided indirect evidence that PCDH8 has cancer-promoting properties, this association is controversial. In particular, its involvement in thyroid cancer (THCA) remains unclear. We aimed to elucidate the role of PCDH8 in THCA using bioinformatic analysis. Subsequently, the results were experimentally validated. The analysis conducted using the R programming language and online web tools explored PCDH8 expression levels, prognostic, and clinical implications, and its relationship with the tumor immune microenvironment in THCA. Furthermore, we examined the association between PCDH8 and co-expressed genes, highlighting their involvement in several biological processes relevant to THCA. The potential of PCDH8 as a therapeutic target for this pathology was also explored. Immunohistochemical (IHC) staining was performed on samples from 98 patients with THCA, and experimental validation was carried out. PCDH8 was significantly elevated in cancer tissues and associated with poor prognosis, several clinical factors, and immune cell and checkpoint abundance. Cox regression and survival analyses, together with Receiver Operating Curves (ROC) indicated that PCDH8 was an independent prognostic factor for THCA. Furthermore, PCDH8 impacts cell viability and proliferation, promoting tumorigenesis. Also, it influences tumor cell sensitivity to various drugs. Thus, PCDH8 might be a potential therapeutic target for THCA. IHC, cell culture, MTT, and colony formation experiments further confirmed our findings. This analysis provided insights into the potential carcinogenic role of PCDH8 in THCA, as it impacts cell viability and proliferation. Thus, PCDH8 might play an important role in its prognosis, immune infiltration, and diagnosis. |
| doi_str_mv | 10.1007/s10142-024-01312-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10874333</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2927881685</sourcerecordid><originalsourceid>FETCH-LOGICAL-c459t-327d2d1ccb42a2ab49904770d6ff1345c34499c4ea0182279fbe4e168d90b2223</originalsourceid><addsrcrecordid>eNqFkU1vEzEQhi0EoiXwBzggS1y4LIw93l37hFAKLVIlOIDEzfJ6vanLxg72JlL-Pd6kDR8H8MXWzDMfr19CnjN4zQDaN5kBE7wCLipgyHiFD8g5EyirVgn58PTGb2fkSc63AFCDwsfkDCU2EgHPifu8vLiS1GdqaIg7N9JNiqsQ8-Qt7Xxcm_TdJeoDnW72KfqeWhNsiZjQz-g6Ti5T68ZD4egHl8zkYzjkd950fvTT_il5NJgxu2d394J8_fD-y_Kquv50-XH57rqyolZThbztec-s7QQ33HRCKRBtC30zDAxFbVGUkBXOAJOct2ronHCskb2CjnOOC_L22Hez7dauty5MyYx6k3zRsdfReP1nJvgbvYo7zUC2AstZkFd3HVL8sXV50mufZ3kmuLjNGlmNDWesUf9FueKSC2RKFvTlX-ht3KZQvmKmWimLhrpQ_EjZFHNObjgtzkDPjuuj47o4rg-O63nhF79LPpXcW1wAPAK5pMLKpV-z_9H2JwFwtnw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2927881685</pqid></control><display><type>article</type><title>PCDH8 is a novel prognostic biomarker in thyroid cancer and promotes cell proliferation and viability</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Yang, Ruida ; Yang, Nan ; Yin, Pan ; Xue, Zihan ; Sun, Feidi ; Fan, Ruihan ; Liang, JiaFu ; Lv, Xinru ; Wu, Shaobo ; Sun, Liankang</creator><creatorcontrib>Yang, Ruida ; Yang, Nan ; Yin, Pan ; Xue, Zihan ; Sun, Feidi ; Fan, Ruihan ; Liang, JiaFu ; Lv, Xinru ; Wu, Shaobo ; Sun, Liankang</creatorcontrib><description>Protocadherin 8 (PCDH8), a calcium-dependent transmembrane protein in the protocadherin family, regulates cell adhesion and signal transduction. While some studies have provided indirect evidence that PCDH8 has cancer-promoting properties, this association is controversial. In particular, its involvement in thyroid cancer (THCA) remains unclear. We aimed to elucidate the role of PCDH8 in THCA using bioinformatic analysis. Subsequently, the results were experimentally validated. The analysis conducted using the R programming language and online web tools explored PCDH8 expression levels, prognostic, and clinical implications, and its relationship with the tumor immune microenvironment in THCA. Furthermore, we examined the association between PCDH8 and co-expressed genes, highlighting their involvement in several biological processes relevant to THCA. The potential of PCDH8 as a therapeutic target for this pathology was also explored. Immunohistochemical (IHC) staining was performed on samples from 98 patients with THCA, and experimental validation was carried out. PCDH8 was significantly elevated in cancer tissues and associated with poor prognosis, several clinical factors, and immune cell and checkpoint abundance. Cox regression and survival analyses, together with Receiver Operating Curves (ROC) indicated that PCDH8 was an independent prognostic factor for THCA. Furthermore, PCDH8 impacts cell viability and proliferation, promoting tumorigenesis. Also, it influences tumor cell sensitivity to various drugs. Thus, PCDH8 might be a potential therapeutic target for THCA. IHC, cell culture, MTT, and colony formation experiments further confirmed our findings. This analysis provided insights into the potential carcinogenic role of PCDH8 in THCA, as it impacts cell viability and proliferation. Thus, PCDH8 might play an important role in its prognosis, immune infiltration, and diagnosis.</description><identifier>ISSN: 1438-793X</identifier><identifier>EISSN: 1438-7948</identifier><identifier>DOI: 10.1007/s10142-024-01312-3</identifier><identifier>PMID: 38368303</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animal Genetics and Genomics ; Biochemistry ; Bioinformatics ; Biomarkers ; Biomedical and Life Sciences ; Calcium ; Carcinogenesis ; carcinogenicity ; Cell adhesion ; Cell Biology ; Cell culture ; Cell growth ; Cell Proliferation ; Cell viability ; Drug development ; family ; genomics ; Humans ; Immunohistochemistry ; Immunosuppressive agents ; Life Sciences ; Medical diagnosis ; Medical prognosis ; Metastases ; Microbial Genetics and Genomics ; Microenvironments ; neoplasm cells ; Original ; Original Article ; Plant Genetics and Genomics ; Prognosis ; Protocadherin ; Protocadherins ; Regression analysis ; Signal transduction ; Survival analysis ; Targeted cancer therapy ; Therapeutic targets ; therapeutics ; Thyroid cancer ; thyroid neoplasms ; Thyroid Neoplasms - genetics ; transmembrane proteins ; Tumor Microenvironment ; Tumorigenesis</subject><ispartof>Functional & integrative genomics, 2024-04, Vol.24 (2), p.35-35, Article 35</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c459t-327d2d1ccb42a2ab49904770d6ff1345c34499c4ea0182279fbe4e168d90b2223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10142-024-01312-3$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10142-024-01312-3$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38368303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Ruida</creatorcontrib><creatorcontrib>Yang, Nan</creatorcontrib><creatorcontrib>Yin, Pan</creatorcontrib><creatorcontrib>Xue, Zihan</creatorcontrib><creatorcontrib>Sun, Feidi</creatorcontrib><creatorcontrib>Fan, Ruihan</creatorcontrib><creatorcontrib>Liang, JiaFu</creatorcontrib><creatorcontrib>Lv, Xinru</creatorcontrib><creatorcontrib>Wu, Shaobo</creatorcontrib><creatorcontrib>Sun, Liankang</creatorcontrib><title>PCDH8 is a novel prognostic biomarker in thyroid cancer and promotes cell proliferation and viability</title><title>Functional & integrative genomics</title><addtitle>Funct Integr Genomics</addtitle><addtitle>Funct Integr Genomics</addtitle><description>Protocadherin 8 (PCDH8), a calcium-dependent transmembrane protein in the protocadherin family, regulates cell adhesion and signal transduction. While some studies have provided indirect evidence that PCDH8 has cancer-promoting properties, this association is controversial. In particular, its involvement in thyroid cancer (THCA) remains unclear. We aimed to elucidate the role of PCDH8 in THCA using bioinformatic analysis. Subsequently, the results were experimentally validated. The analysis conducted using the R programming language and online web tools explored PCDH8 expression levels, prognostic, and clinical implications, and its relationship with the tumor immune microenvironment in THCA. Furthermore, we examined the association between PCDH8 and co-expressed genes, highlighting their involvement in several biological processes relevant to THCA. The potential of PCDH8 as a therapeutic target for this pathology was also explored. Immunohistochemical (IHC) staining was performed on samples from 98 patients with THCA, and experimental validation was carried out. PCDH8 was significantly elevated in cancer tissues and associated with poor prognosis, several clinical factors, and immune cell and checkpoint abundance. Cox regression and survival analyses, together with Receiver Operating Curves (ROC) indicated that PCDH8 was an independent prognostic factor for THCA. Furthermore, PCDH8 impacts cell viability and proliferation, promoting tumorigenesis. Also, it influences tumor cell sensitivity to various drugs. Thus, PCDH8 might be a potential therapeutic target for THCA. IHC, cell culture, MTT, and colony formation experiments further confirmed our findings. This analysis provided insights into the potential carcinogenic role of PCDH8 in THCA, as it impacts cell viability and proliferation. Thus, PCDH8 might play an important role in its prognosis, immune infiltration, and diagnosis.</description><subject>Animal Genetics and Genomics</subject><subject>Biochemistry</subject><subject>Bioinformatics</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Calcium</subject><subject>Carcinogenesis</subject><subject>carcinogenicity</subject><subject>Cell adhesion</subject><subject>Cell Biology</subject><subject>Cell culture</subject><subject>Cell growth</subject><subject>Cell Proliferation</subject><subject>Cell viability</subject><subject>Drug development</subject><subject>family</subject><subject>genomics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Immunosuppressive agents</subject><subject>Life Sciences</subject><subject>Medical diagnosis</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Microbial Genetics and Genomics</subject><subject>Microenvironments</subject><subject>neoplasm cells</subject><subject>Original</subject><subject>Original Article</subject><subject>Plant Genetics and Genomics</subject><subject>Prognosis</subject><subject>Protocadherin</subject><subject>Protocadherins</subject><subject>Regression analysis</subject><subject>Signal transduction</subject><subject>Survival analysis</subject><subject>Targeted cancer therapy</subject><subject>Therapeutic targets</subject><subject>therapeutics</subject><subject>Thyroid cancer</subject><subject>thyroid neoplasms</subject><subject>Thyroid Neoplasms - genetics</subject><subject>transmembrane proteins</subject><subject>Tumor Microenvironment</subject><subject>Tumorigenesis</subject><issn>1438-793X</issn><issn>1438-7948</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNqFkU1vEzEQhi0EoiXwBzggS1y4LIw93l37hFAKLVIlOIDEzfJ6vanLxg72JlL-Pd6kDR8H8MXWzDMfr19CnjN4zQDaN5kBE7wCLipgyHiFD8g5EyirVgn58PTGb2fkSc63AFCDwsfkDCU2EgHPifu8vLiS1GdqaIg7N9JNiqsQ8-Qt7Xxcm_TdJeoDnW72KfqeWhNsiZjQz-g6Ti5T68ZD4egHl8zkYzjkd950fvTT_il5NJgxu2d394J8_fD-y_Kquv50-XH57rqyolZThbztec-s7QQ33HRCKRBtC30zDAxFbVGUkBXOAJOct2ronHCskb2CjnOOC_L22Hez7dauty5MyYx6k3zRsdfReP1nJvgbvYo7zUC2AstZkFd3HVL8sXV50mufZ3kmuLjNGlmNDWesUf9FueKSC2RKFvTlX-ht3KZQvmKmWimLhrpQ_EjZFHNObjgtzkDPjuuj47o4rg-O63nhF79LPpXcW1wAPAK5pMLKpV-z_9H2JwFwtnw</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Yang, Ruida</creator><creator>Yang, Nan</creator><creator>Yin, Pan</creator><creator>Xue, Zihan</creator><creator>Sun, Feidi</creator><creator>Fan, Ruihan</creator><creator>Liang, JiaFu</creator><creator>Lv, Xinru</creator><creator>Wu, Shaobo</creator><creator>Sun, Liankang</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20240401</creationdate><title>PCDH8 is a novel prognostic biomarker in thyroid cancer and promotes cell proliferation and viability</title><author>Yang, Ruida ; 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While some studies have provided indirect evidence that PCDH8 has cancer-promoting properties, this association is controversial. In particular, its involvement in thyroid cancer (THCA) remains unclear. We aimed to elucidate the role of PCDH8 in THCA using bioinformatic analysis. Subsequently, the results were experimentally validated. The analysis conducted using the R programming language and online web tools explored PCDH8 expression levels, prognostic, and clinical implications, and its relationship with the tumor immune microenvironment in THCA. Furthermore, we examined the association between PCDH8 and co-expressed genes, highlighting their involvement in several biological processes relevant to THCA. The potential of PCDH8 as a therapeutic target for this pathology was also explored. Immunohistochemical (IHC) staining was performed on samples from 98 patients with THCA, and experimental validation was carried out. PCDH8 was significantly elevated in cancer tissues and associated with poor prognosis, several clinical factors, and immune cell and checkpoint abundance. Cox regression and survival analyses, together with Receiver Operating Curves (ROC) indicated that PCDH8 was an independent prognostic factor for THCA. Furthermore, PCDH8 impacts cell viability and proliferation, promoting tumorigenesis. Also, it influences tumor cell sensitivity to various drugs. Thus, PCDH8 might be a potential therapeutic target for THCA. IHC, cell culture, MTT, and colony formation experiments further confirmed our findings. This analysis provided insights into the potential carcinogenic role of PCDH8 in THCA, as it impacts cell viability and proliferation. Thus, PCDH8 might play an important role in its prognosis, immune infiltration, and diagnosis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38368303</pmid><doi>10.1007/s10142-024-01312-3</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animal Genetics and Genomics Biochemistry Bioinformatics Biomarkers Biomedical and Life Sciences Calcium Carcinogenesis carcinogenicity Cell adhesion Cell Biology Cell culture Cell growth Cell Proliferation Cell viability Drug development family genomics Humans Immunohistochemistry Immunosuppressive agents Life Sciences Medical diagnosis Medical prognosis Metastases Microbial Genetics and Genomics Microenvironments neoplasm cells Original Original Article Plant Genetics and Genomics Prognosis Protocadherin Protocadherins Regression analysis Signal transduction Survival analysis Targeted cancer therapy Therapeutic targets therapeutics Thyroid cancer thyroid neoplasms Thyroid Neoplasms - genetics transmembrane proteins Tumor Microenvironment Tumorigenesis |
| title | PCDH8 is a novel prognostic biomarker in thyroid cancer and promotes cell proliferation and viability |
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