Ultrahigh frequencies of peripherally matured LGI1- and CASPR2-reactive B cells characterize the cerebrospinal fluid in autoimmune encephalitis

Intrathecal synthesis of central nervous system (CNS)-reactive autoantibodies is observed across patients with autoimmune encephalitis (AE), who show multiple residual neurobehavioral deficits and relapses despite immunotherapies. We leveraged two common forms of AE, mediated by leucine-rich glioma...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2024-02, Vol.121 (7), p.e2311049121-e2311049121
Hauptverfasser:	Theorell, Jakob, Harrison, Ruby, Williams, Robyn, Raybould, Matthew I J, Zhao, Meng, Fox, Hannah, Fower, Andrew, Miller, Georgina, Wu, Zoe, Browne, Eleanor, Mgbachi, Victor, Sun, Bo, Mopuri, Rohini, Li, Ying, Waters, Patrick, Deane, Charlotte M, Handel, Adam, Makuch, Mateusz, Irani, Sarosh R
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Autoantibodies Autoantigens Autoimmune diseases Autoimmune Diseases of the Nervous System B-cell receptor Biological Sciences Cell differentiation Central nervous system Cerebrospinal fluid Contactin Encephalitis Glioma Hashimoto Disease Humans Immunoglobulin G Immunotherapy Intracellular Signaling Peptides and Proteins Leucine LGI1 protein Lymphocytes Lymphocytes B Lymphocytes T Monoclonal antibodies Neoplasm Recurrence, Local Receptors T cell receptors Ultrahigh frequencies
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