Interferon-α receptor antisense oligonucleotides reduce neuroinflammation and neuropathology in a mouse model of cerebral interferonopathy

Chronic and elevated levels of the antiviral cytokine IFN-α in the brain are neurotoxic. This is best observed in patients with genetic cerebral interferonopathies such as Aicardi-Goutières syndrome. Cerebral interferonopathies typically manifest in early childhood and lead to debilitating disease a...

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Veröffentlicht in:	The Journal of clinical investigation 2024-02, Vol.134 (4)
Hauptverfasser:	Viengkhou, Barney, Hong, Christine, Mazur, Curt, Damle, Sagar, Gallo, Nicholas B, Fang, Terry C, Henry, Kate, Campbell, Iain L, Kamme, Fredrik, Hofer, Markus J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Child, Preschool Humans Interferon Type I Interferon-alpha - genetics Mice Mice, Transgenic Nervous System Diseases Neuroinflammatory Diseases Oligonucleotides, Antisense - genetics Oligonucleotides, Antisense - pharmacology
Online-Zugang:	Volltext
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