The mineralocorticoid receptor forms higher order oligomers upon DNA binding

The prevailing model of steroid hormone nuclear receptor function assumes ligand‐induced homodimer formation followed by binding to DNA hormone response elements (HREs). This model has been challenged by evidence showing that the glucocorticoid receptor (GR) forms tetramers upon ligand and DNA bindi...

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Veröffentlicht in:	Protein science 2024-03, Vol.33 (3), p.e4890-n/a
Hauptverfasser:	Fettweis, Gregory, Johnson, Thomas A., Almeida‐Prieto, Brian, Weller‐Pérez, Julián, Presman, Diego M., Hager, Gordon L., Alvarez de la Rosa, Diego
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Hormones aldosterone Antagonists Binding corticosterone Deoxyribonucleic acid DNA DNA - metabolism glucocorticoid receptor Glucocorticoid receptors Glucocorticoids Imaging techniques Ligands mineralocorticoid receptor Mineralocorticoid receptors Oligomerization Oligomers Protein structure Quaternary structure Receptors Receptors, Cytoplasmic and Nuclear Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Receptors, Mineralocorticoid - genetics Receptors, Mineralocorticoid - metabolism Regulatory sequences Steroids
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