Engineering Cas9: next generation of genomic editors

The Cas9 endonuclease of the CRISPR/Cas type IIA system from Streptococcus pyogenes is the heart of genome editing technology that can be used to treat human genetic and viral diseases. Despite its large size and other drawbacks, S. pyogenes Cas9 remains the most widely used genome editor. A vast am...

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Veröffentlicht in:	Applied microbiology and biotechnology 2024-12, Vol.108 (1), p.209, Article 209
Hauptverfasser:	Kovalev, Maxim A., Davletshin, Artem I., Karpov, Dmitry S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biotechnology CRISPR CRISPR-Associated Protein 9 - genetics CRISPR-Cas Systems Directed evolution Endonuclease Genome editing Genomes Genomics Humans Immunogenicity Life Sciences Microbial Genetics and Genomics Microbiology Mini-Review Mutagenesis Mutation Proteins Streptococcus pyogenes - genetics Viral diseases
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