p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndrome

The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth, metabolism and autophagy. Multiple pathways modulate mTORC1 in response to nutrients. Here we describe that nucleus–cytoplasmic shuttling of p300/EP300 regulates mTORC1 activity in response to amino acid or...

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Veröffentlicht in:	Nature cell biology 2024-02, Vol.26 (2), p.235-249
Hauptverfasser:	Son, Sung Min, Park, So Jung, Breusegem, Sophia Y., Larrieu, Delphine, Rubinsztein, David C.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/109 13/44 13/51 13/95 14/19 14/35 38/1 38/70 631/80/86/2369 692/699 Acetylation Active Transport, Cell Nucleus Amino acids Amino Acids - metabolism AMP-activated protein kinase Animals Autophagy Biomedical and Life Sciences Cancer Research Cell Biology Cytoplasm Dephosphorylation Developmental Biology Humans Kinases Lamin Type A - genetics Lamin Type A - metabolism Life Sciences Mechanistic Target of Rapamycin Complex 1 - metabolism Mice Nuclei (cytology) Nutrient status Nutrients Phenotypes Phosphoprotein phosphatase Phosphorylation Progeria Progeria - genetics Progeria - metabolism Protein phosphatase Proteins Rapamycin Regulatory-Associated Protein of mTOR - metabolism Stem Cells TOR protein
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