Piezo1 agonist restores meningeal lymphatic vessels, drainage, and brain-CSF perfusion in craniosynostosis and aged mice

Skull development coincides with the onset of cerebrospinal fluid (CSF) circulation, brain-CSF perfusion, and meningeal lymphangiogenesis, processes essential for brain waste clearance. How these processes are affected by craniofacial disorders such as craniosynostosis are poorly understood. We repo...

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Veröffentlicht in:	The Journal of clinical investigation 2024-02, Vol.134 (4), p.1-17
Hauptverfasser:	Matrongolo, Matt J, Ang, Phillip S, Wu, Junbing, Jain, Aditya, Thackray, Joshua K, Reddy, Akash, Sung, Chi Chang, Barbet, Gaëtan, Hong, Young-Kwon, Tischfield, Max A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Agonists Alzheimer's disease Animal models Animals Birth defects Brain - metabolism Cerebrospinal fluid Craniosynostoses - drug therapy Craniosynostoses - genetics Craniosynostoses - metabolism Craniosynostosis Drainage Extracellular matrix Glymphatic System - metabolism Growth factors Intracranial pressure Ion Channels - genetics Ion Channels - metabolism Lymph nodes Lymphatic system Lymphatic Vessels - metabolism Mice Mutation Neurodegenerative diseases Perfusion Sinuses Smooth muscle Surgical drains Sutures
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