Nivolumab Therapy in Lung Cancer Associated with IgG4-related Disease
A 75-year-old man with severe bilateral pleural thickening and dense soft tissue masses surrounding the abdominal aorta on computed tomography was diagnosed with IgG4-related disease (IgG4-RD) as a complication of lung cancer. He was started on nivolumab as second-line therapy along with low-dose pr...
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| Veröffentlicht in: | Internal Medicine 2024/01/15, Vol.63(2), pp.283-287 |
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| container_title | Internal Medicine |
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| creator | Aso, Mari Suzuki, Hiroki Aizawa, Takafumi Nawa, Sachie Ota, Hiroki Nogawa, Hitomi Hino, Toshihiko |
| description | A 75-year-old man with severe bilateral pleural thickening and dense soft tissue masses surrounding the abdominal aorta on computed tomography was diagnosed with IgG4-related disease (IgG4-RD) as a complication of lung cancer. He was started on nivolumab as second-line therapy along with low-dose prednisolone. Nivolumab was administered for 15 months until disease progression, during which time IgG4-RD did not relapse, and no problematic immune-related adverse events occurred. These results suggest that anti-programmed cell death protein-1 antibody may be used safely in lung cancer associated with IgG4-RD concomitantly with low-dose steroids. |
| doi_str_mv | 10.2169/internalmedicine.1480-22 |
| format | Article |
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He was started on nivolumab as second-line therapy along with low-dose prednisolone. Nivolumab was administered for 15 months until disease progression, during which time IgG4-RD did not relapse, and no problematic immune-related adverse events occurred. 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| ispartof | Internal Medicine, 2024/01/15, Vol.63(2), pp.283-287 |
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| subjects | anti-programmed cell death protein-1 antibody Aorta Apoptosis Case Report Cell death Computed tomography IgG4-related disease Immunoglobulin G low-dose steroid Lung cancer nivolumab Prednisolone Steroid hormones |
| title | Nivolumab Therapy in Lung Cancer Associated with IgG4-related Disease |
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