EZH2 inhibition promotes tumor immunogenicity in lung squamous cell carcinomas

Two important factors that contribute to resistance to immune checkpoint inhibitors (ICIs) are an immune-suppressive microenvironment and limited antigen presentation by tumor cells. In this study, we examine if inhibition of the methyltransferase EZH2 can increase ICI response in lung squamous cell...

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Veröffentlicht in:	Cancer research communications 2024-02, Vol.4 (2), p.388-403
Hauptverfasser:	DuCote, Tanner J, Song, Xiulong, Naughton, Kassandra J, Chen, Fan, Plaugher, Daniel R, Childress, Avery R, Gellert, Abigail R, Skaggs, Erika M, Qu, Xufeng, Liu, Jinze, Liu, Jinpeng, Li, Fei, Wong, Kwok-Kin, Brainson, Christine F
Format:	Artikel
Sprache:	eng
Schlagworte:	Epigenetics Immunotherapy Lung Cancer Small Molecule Agents
Online-Zugang:	Volltext
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