Dysregulated palmitic acid metabolism promotes the formation of renal calcium-oxalate stones through ferroptosis induced by polyunsaturated fatty acids/phosphatidic acid

The pathogenesis of renal calcium-oxalate (CaOx) stones is complex and influenced by various metabolic factors. In parallel, palmitic acid (PA) has been identified as an upregulated lipid metabolite in the urine and serum of patients with renal CaOx stones via untargeted metabolomics. Thus, this stu...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2024-12, Vol.81 (1), p.85-85, Article 85
Hauptverfasser:	Wang, Rui, Zhang, Jingdong, Ren, Haotian, Qi, Shiyong, Xie, Linguo, Xie, Haijie, Shang, Zhiqun, Liu, Chunyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion arachidonate 15-lipoxygenase Biochemistry Biomedical and Life Sciences Biomedicine blood serum Calcium Calcium oxalate Calcium Oxalate - chemistry Cell adhesion molecules Cell Biology Crystals Desaturase Epithelial cells Epithelium Ethanolamine fatty acid desaturase fatty acid metabolism Fatty acids Fatty Acids, Unsaturated Ferroptosis Gene expression Humans Kidneys Kinases Life Sciences Linoleic acid Linolenic acid Lipid metabolism Lipid peroxidation lipidomics Lipids Lipoxygenase Metabolism Metabolites Metabolomics Original Original Article Oxalic acid Oxidative stress Palmitic acid Palmitic Acids Pathogenesis Peroxidation Peroxides Peroxisome proliferator-activated receptors Phosphatidic acid phosphatidic acids Phosphorylation Polyunsaturated fatty acids PPAR alpha Protein kinase C Proteins Stone Transcriptomics urine
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