ALDH2 dysfunction and alcohol cooperate in cancer stem cell enrichment

Abstract The alcohol metabolite acetaldehyde is a potent human carcinogen linked to esophageal squamous cell carcinoma (ESCC) initiation and development. Aldehyde dehydrogenase 2 (ALDH2) is the primary enzyme that detoxifies acetaldehyde in the mitochondria. Acetaldehyde accumulation causes genotoxi...

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Veröffentlicht in:	Carcinogenesis (New York) 2024-02, Vol.45 (1-2), p.95-106
Hauptverfasser:	Flashner, Samuel, Shimonosono, Masataka, Tomita, Yasuto, Matsuura, Norihiro, Ohashi, Shinya, Muto, Manabu, Klein-Szanto, Andres J, Alan Diehl, J, Chen, Che-Hong, Mochly-Rosen, Daria, Weinberg, Kenneth I, Nakagawa, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaldehyde - metabolism Alcohol Dehydrogenase - genetics Alcohol Drinking - genetics Aldehyde Dehydrogenase - genetics Aldehyde Dehydrogenase - metabolism Aldehyde Dehydrogenase, Mitochondrial - genetics Animals Carcinogenesis Cell Transformation, Neoplastic Cisplatin - pharmacology Editor's Choice Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma - genetics Ethanol - metabolism Humans Mice Neoplastic Stem Cells - pathology Risk Factors
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